姓名：付钰
职务/职称：教授，博士生导师
通讯地址：中南民族大学生科院8-D-201室
E-mail：fuyu@mail.scuec.edu.cn
主要基于多学科交叉，开展大健康微生物组（One Health Microbiome）研究，聚焦于利用拉曼光谱、类器官和人工智能等技术解析肠道微生物与人体健康，环境微生物与地球健康的关联，发掘开发One Health产品。主持或参与国家自然科学基金项目5项，国家重点研发项目3项，中科院前沿交叉团队项目1项，获英国皇家协会Newton Advanced Fellowship，第一届“率先杯”未来技术创新大赛优胜奖等奖项，入选国家“海外高层次人才引进计划”青年项目。
一、学习及工作简历：
2025.11-至今， 中南民族大学生命科学学院教授
2013.1-2025.10 中国科学院微生物研究所研究员
2008.5-2012.12 博士后，哈佛大学医学院生物化学与分子药理学系
2003.09-2008.05，博士，加拿大萨斯喀彻温大学医学院微生物与免疫学系
2000.09-2003.08，硕士，加拿大萨斯喀彻温大学医学院微生物与免疫学系
1999.09-2000.08，瑞士诺华制药公司Friedrich Miesche Institute研究助理
1997.09-1999.08，中国科学院遗传与发育研究所研实员
1994.09-1997.08 硕士，中国科学院遗传与发育研究所
1990.09-1994.08 本科，湖北大学生命科学系
二、近五年主持或参与的主要科研项目
1. 新发突发与重大传染病防控国家科技重大专项，2025ZD01900100，千万级国家未知病原微生物样本保藏库构建，2025/12-2028/11，2980万，在研，参与
2. 国家自然科学基金重大疫情的环境安全与次生风险防控重大项目，52091541，环境介质中的病毒识别与传播规律，400万，2021/01-2025/12，结项，参与
3. 北京市自然科学基金外籍学者项目，IS23089，拉曼光谱结合人工智能技术无损鉴定微生物及活体水平的微生物单细胞生理生化表征研究， 2023/10-2025/09，20万，结项，主持
4.国家重点研发计划，2019YFA0905500，活性污泥人工多细胞体系构建与应用，2020/01-2024/12，2039万，结项，参与
5. 国家重点研发计划，2021YFC2301000，难培养和微量病原体靶向培养技术研究，2021/12-2024/11，1964万，结项，参与
6. 国家自然科学基金面上项目，31970553，利用单分子技术解析酿酒酵母H1类似蛋白Hho1和Hmo1的生理功能及对应的分子机理，58万，2000/01-2023/12，结项，主持
三、代表性论文：（*通讯作者）
1.Zhang, Z., andFu, Y.V.*(2025). From spectrum to species: A new era of medical microbiology with AI-powered Raman spectroscopy.hLife3, 527–530.
2.王艺璇,张书娟,付钰*(2025).子宫内膜异位症相关微生物组的研究进展.微生物学报65, 4254–4271.
3.Wang, Y., Zhang, S., Han, S. L., Ge, X., Gao, S., Zhu, Q., Liu, Y., Hu, S., Jiang, Z., Dai, Y., Cai, L.,Fu, Y. V.*(2025). Whole-genome sequencing and comparative genomic analysis of Irpex lacteus isolated from the female reproductive tract.Microb Genom11(6):001416.
4.Liu, L., Xue, J., Song, Y., Zhan, T., Liu, Y., Song, X., Mei, L., Wang, D.,Fu, Y. V.*, Wei, Q.* (2025). "A Pilot Study on Single-Cell Raman Spectroscopy Combined with Machine Learning for Phenotypic Characterization of Staphylococcus aureus."Microorganisms13(6):1333
5.张书娟，刘晓秋，钟宇新*，付钰*(2025).肠道微生物与高尿酸血症的关联及创新性治疗.生物工程学报41(6):2290-2309.
6.蒋子雯,王艺璇，任建，唐世倩，靳灵鸽，张宇迪，代荫梅*，付钰*(2024).女性上生殖道菌群与妇产疾病的关系：研究进展与展望.微生物学通报51(12): 4842-4853.
7.Xue, J., Yue, H., Lu, W., Li, Y., Huang, G.*, andFu, Y.V.*(2024). Application of Raman spectroscopy and machine learning forCandida aurisidentification and characterization.Applied and Environmental Microbiology, e0102524.
8.Wang, L., Lu, W., Song, Y., Liu, S., andFu, Y.V.* (2024). Using machine learning to identify environmental factors that collectively determine microbial community structure of activated sludge.Environ Res260, 119635.
9.Huang, L., Lu, W., Yu, Y., Qiu, H., Zeng, Y., Wang, L., Liu, Y., Yan, L.,Fu, Y.V.*, and Zheng, Y.* (2024). The ammonium transporter AmtB is dispensable for the uptake of ammonium in the phototrophic diazotrophRhodopseudomonas palustris.Environmental Technology & Innovation36.
10.Ji, X., Xue, J., Shi, J., Wang, W., Zhang, X., Wang, Z., Lu, W., Liu, J.,Fu, Y.V.*, and Xu, N.* (2024). Noninvasive Raman spectroscopy for the detection of rice bacterial leaf blight and bacterial leaf streak.Talanta282.
11.Ke, W., Xie, Y., Chen, Y., Ding, H., Ye, L., Qiu, H., Li, H., Zhang, L., Chen, L., Tian, X., Shen, Z., Song, Z., Fan, X., Zong, J. F., Guo, Z., Ma, X., Xiao, M., Liao, G., Liu, C. H., Yin, W. B., Dong, Z., Yang, F., Jiang, Y. Y., Perlin, D. S., Chen, Y.,Fu, Y.V.*, and Wang, L.* (2024). Fungicide-tolerant persister formation during cryptococcal pulmonary infection.CellHost &Microbe32, 276-289 e277.
12.Lu, W., Wang, L., Liang, J., Lu, Y., Wang, J., andFu, Y.V.*(2023). Dynamically Quantifying Intracellular Elemental Sulfur and Predicting Pertinent Gene Transcription by Raman Spectroscopy in Living Cells.Analytical Chemistry95, 9769-9778.
13.Wang, M., Li, J., Wang, Y., Fu, H., Qiu, H., Li, Y., Li, M., Lu, Y., andFu, Y.V.*(2023). Single-molecule study reveals Hmo1, not Hho1, promotes chromatin assembly in budding yeast.mBio, e0099323.
14.Liu, Y., Zhang, Y., Zhao, X., Lu, W., Zhong, Y., andFu, Y.V. *(2023). Antifungal Peptide SP1 Damages Polysaccharide Capsule ofCryptococcus neoformansand Enhances Phagocytosis of Macrophages.Microbiol Spectr, e0456222.
15.Lu, W., Li, H., Qiu, H., Wang, L., Feng, J., and Fu, Y.V. (2023). Identification of pathogens and detection of antibiotic susceptibility at single-cell resolution by Raman spectroscopy combined with machine learning.Frontiers in Microbiology13, 1076965.
16.Liu, Y., Shao, Y., Wang, L., Lu, W., Li, S., Xu, D., andFu, Y.V.*(2022). Inactivation of porcine epidemic diarrhea virus with electron beam irradiation under cold chain conditions.Environ Technol Innov, 102715.
17.Zhang, Y., Zhou, L., Liu, Y., Zhao, X., Lian, X., Zhang, J., Zhao, D., Wang, Y., Zhong, J., Wang, J., Wang, H., Wang, L.*,Fu, Y.V.*(2022). A Peptide from Budding Yeast GAPDH Serves as a Promising Antifungal againstCryptococcus neoformans.Microbiol Spectr10, e0082621.
18.Zhao, X., Lian, X., Liu, Y., Zhou, L., Wu, B., andFu, Y.V.*(2022). A Peptide Derived from GAPDH Enhances Resistance to DNA Damage inSaccharomyces cerevisiaeCells.Applied and Environmental Microbiology88, e0219421.
19.卢维来,许添顺,汤晖,蒋靖坤,付钰*(2022).微生物气溶胶检测技术的研究进展.微生物学报62, 1345-1361.
20.Yu, S., Li, X., Lu, W., Li, H.,Fu, Y.V.*, and Liu, F.* (2021). Analysis of Raman Spectra by Using Deep Learning Methods in the Identification of Marine Pathogens.Analytical Chemistry93, 11089-11098.
21.Wang, Z., Liu, Y., Lu, W.,Fu, Y.V.*, and Zhou, Z.* (2021). Blood identification at the single-cell level based on a combination of laser tweezers Raman spectroscopy and machine learning.Biomed Opt Express12, 7568-7581.
22.Wang, Y., andFu, Y.V.*(2021). Yeast Nucleoplasmic Extracts and an Application to Visualize Chromatin Assembly on Single Molecules of DNA.Methods in Molecular Biology2196, 199-209.
23.Wang, Q.,Fu, Y.V.*, and Xiao, W.* (2021). Scarless Genomic Protein Labeling inSaccharomyces cerevisiae.Methods in Molecular Biology2196, 63-75.
24.Zhang, Z., Zhan, Z., Wang, B., Chen, Y., Chen, X., Wan, C.,Fu, Y.*, and Huang, L*. (2020). Archaeal Chromatin Proteins Cren7 and Sul7d Compact DNA by Bending and Bridging.mBio11.
25.Yu, S., Li, H., Li, X.,Fu, Y.V.*, and Liu, F.* (2020). Classification of pathogens by Raman spectroscopy combined with generative adversarial networks.Sci Total Environ726, 138477.
26.Lu, W., Chen, X., Wang, L., Li, H., andFu, Y.V.*(2020). Combination of an Artificial Intelligence Approach and Laser Tweezers Raman Spectroscopy for Microbial Identification.Analytical Chemistry92, 6288-6296.
27.周利艳,付钰*(2019).一种制备新生隐球菌单细胞的方法.微生物学报59, 326-333.
28.Wang, Y., Zhang, K., Li, H., Xu, X., Xue, H., Wang, P., andFu, Y.V.*(2019). Fine-tuning the expression of target genes using a DDI2 promoter gene switch in budding yeast.Sci Rep9, 12538.
29.Chen, Y., Zhan, Z., Zhang, H., Bi, L., Zhang, X.E.*, andFu, Y.V.*(2019). Kinetic analysis of DNA compaction by mycobacterial integration host factor at the single-molecule level.Tuberculosis119, 101862.
30.Xue, H., Zhan, Z., Zhang, K., andFu, Y.V.*(2018). Visualizing the Interaction Between the Qdot-labeled Protein and Site-specifically Modified lambda DNA at the Single Molecule Level.Journal ofVisualizedExperimentse57967.
31.Fan, Q., Xu, X., Zhao, X., Wang, Q., Xiao, W., Guo, Y., andFu, Y.V.*(2018). Rad5 coordinates translesion DNA synthesis pathway by recognizing specific DNA structures inSaccharomyces cerevisiae.Curr Genet64, 889-899.
32.Xue, H., Bei, Y., Zhan, Z., Chen, X., Xu, X., andFu, Y.V.*(2017). Utilizing Biotinylated Proteins Expressed in Yeast to Visualize DNA–Protein Interactions at the Single-Molecule Level.Frontiers in Microbiology8.
33.Zhao De, Chen, X., Li, K., andFu, Y.V.*(2017). The application of thermophilic DNA primase TtDnaG2 to DNA amplification.Sci Rep7, 12809.
34.Zhao, X., Liu, X., Xu, X., andFu, Y.V.*(2017). Microbe social skill: the cell-to-cell communication between microorganisms.Science Bulletin62, 516-524.
35.Wang, Q., Xue, H., Li, S., Chen, Y., Tian, X., Xu, X., Xiao, W., andFu, Y.V.*(2017). A method for labeling proteins with tags at the native genomic loci in budding yeast.PloS one12, e0176184.
36.Fan, Q., andFu, Y.*(2017). Telomere and centromere—DNA tandem arrays on the chromosome.Chinese Science Bulletin62, 3245-3255.
37.Chen, X., Zhao, E., andFu, Y.V.*(2017). Using single-molecule approach to visualize the nucleosome assembly in yeast nucleoplasmic extracts.Science Bulletin62, 399-404.
38.Zhan, Z., Xu, X., andFu, Y.V.*(2016). Single cell tells the developmental story.Science Bulletin61, 1355-1357.
39.许鑫,付钰*(2015).解析DNA损伤应答之路.科学通报60, 3158-3160.
40.Xue, H., Xu, X. andFu, Y.V.*(2015) New insights in pre-replication complex formation with single-molecule visualization.Science Bulletin60(12):1133-1135
41.Fu YV, Yardimci H, Long DT, Ho TV, Guainazzi A, Bermudez VP, Hurwitz J, van Oijen A, Schärer OD, Walter JC* (2011) Selective bypass of a lagging strand roadblock by the eukaryotic replicative DNA helicase.Cell146(6): 931-941
42.Fu YVand Walter JC* (2010) DNA replication: metazoan Sld3 steps forward.Current Biology20(12): 515-517
43.Fu Y, Zhu Y, Zhang K, Yeung M, Durocher D and Xiao W* (2008) Rad6-Rad18 mediates a eukaryotic SOS response by ubiquitinating the 9-1-1 checkpoint clamp.Cell133(4):601-611
四、授权专利
（1）付钰，王琳淇，卢维来，仇昊宁，谢语嫣，一种快速无损检测细胞中麦角硫因的方法，2025.07.22，中国，ZL 202310057609.1
（2）付钰，赵德，一种利用嗜热引发酶扩增DNA的方法，2021.09.21，中国，ZL 201710153877.8
（3） 付钰，李焓菲，卢维来，用于显微拉曼光谱检测好氧或兼性厌氧病原微生物的液体样品池，2021.05.04，中国，ZL 202010198979.3
（4） 付钰，许添顺，卢维来，王璐，李焓菲，一种基于旋转液腔的生物气溶胶收集方法，2020.11.27，中国，ZL 201910869997.7
（5）付钰，连宪强，周利艳，抗真菌肽及其用途，2020.04.21，中国，ZL 201710188194.6
五、软件著作权：
1. 病原体拉曼识别与表征软件，2023.05.16, 登记号：2023SR0919162
2. 一维拉曼数据的二维图像转换软件，2021.08.16，登记号：2021SR1524571
六、教学活动
（1）主讲课程：中国科学院大学研究生课程《微生物学前沿》
实验室秉承创新，严谨，精进，协作的科学精神，打造敢为人先，求真务实，和衷共济，笃行致远的团队文化，热忱欢迎有志于科研的同学报考本团队的博士和硕士研究生，让我们携手开启一段有趣、有用、有苦、有乐、自勉、自强、自信、自豪的人生之旅！
