2016年6月博士毕业于武汉大学。曾先后在美国南达科他大学、美国德克萨斯大学休斯顿健康科学中心担任博士后研究员。2019年10月通过中南民族大学南湖论坛引进，加入生物医学工程学院。

现为美国心脏协会（AHA）会员、中国神经科学学会会员、中国药理学会会员、湖北省生理学会会员、武汉市生理学会理事。受邀担任SCI期刊《Frontiers in Pharmacology》客座编辑及《Journal of Integrative Neuroscience》青年编委，多次担任Stroke、Iscience、Brain Research Bulletin、Clinical Epidemiology等20多个SCI期刊审稿人。同时，担任教育部学位与研究生教育发展中心评审专家。

近年来发表SCI论文20多篇，其中以第一作者或通讯作者身份发表16篇，总引用量超过1000次，其中1篇入选ESI高被引论文。目前主持国家自然科学基金项目1项、湖北省自然科学基金项目2项、中央高校基本科研业务费专项资金项目2项、中南民族大学引进人才项目1项、校企合作项目1项，并参与多个国家级和省级项目。

本课题组主要研究领域为新生儿缺氧缺血性脑病与成年人缺血性脑卒中的发病机制及靶向干预，具体聚焦于：①探究小胶质细胞焦亡及线粒体氧化应激损伤在上述两种疾病中的作用机制；②利用网络药理学、分子对接、SPR、代谢组学和转录组学等技术，筛选可改善上述两种疾病的小分子化合物或中药单体。

神经损伤、修复与再生；神经精神药理学

1．国家自然科学基金，82301574，OTC通过转录因子Purα上调神经元CaMKKβ表达改善HIBD的机制研究，30万，01/2024-12/2026，在研，主持

2．湖北省自然科学基金，2024AFB875，刺囊酸通过PPARγ/NF-κB途径介导小胶质细胞M2极化促进HIBD后髓鞘再生的作用与机制，5万，03/2024 - 03/2026，在研，主持

3．湖北省自然科学基金，2020CFB161，吡格列酮对新生小鼠缺氧缺血性脑损伤的神经保护作用及其机制研究，5万，03/2020 - 03/2022，已结题，主持

4．中央高校基本科研业务费专项资金项目，CZQ23030，基于CaMKKβ/CaMKIV/CREB信号轴介导的神经发生探究音乐疗法对新生小鼠HIBD的脑保护作用机制，5万，04/2023-04/2025，在研，主持

5．中南民族大学海外优秀人才引进项目，YZZ19018，新生儿缺氧缺血性脑病的新药研发，200万，10/2019-10/2024，已结题，主持

1．Da Zheng, Zhang H, Zou YK, Yang JY, He SY, Peng HJ, Liu JX, Qi SH, Min JW* Purα overexpression mitigates neonatal hypoxic-ischemic brain damage by inhibiting neuronal pyroptosis via the P2X7R/NLRP3/Caspase-1 pathway. Brain Res Bull. 2026 Feb;235:111726

2．Qin XD, Li YR, Cai Q, Liu JY, Dang ZH, Li LL, Min JW*, Qi SH*, Bu F*. Profiling X chromosome genes expression relevant to sex dimorphism in stroke: insights from transcriptomics landscape analysis. Front Genet. 2025 Mar 21;16:1479270.

3．Liu XJ, Zheng D, Chen L, Chen S*, Min JW*. Nuclear Factor Erythroid 2-Related Factor 2 as a Potential Therapeutic Target in Neonatal Hypoxic-Ischemic Encephalopathy.  J Integr Neurosci. 2024, 23(5), 103.

4．Chen L, Chen S, Yang XF, Min JW*. Antioxidants attenuate mitochondrial oxidative damage through the Nrf2 pathway: A promising therapeutic strategy for stroke. J Neurosci Res 2023. 101(8), 1275–1288.

5．Li Y, Chen L, Zheng D, Liu JX, Liu C, Qi SH, Hu PC, Yang XF and Min JW*. Echinocystic acid alleviated hypoxic-ischemic brain damage in neonatal mice by activating the PI3K/Akt/ Nrf2 signaling pathway. Front. Pharmacol. (2023)14:1103265.

6．Li Y, Zhang JJ, Chen RJ, Chen L, Chen S, Yang XF, Min JW*. Genistein Mitigates Oxidative Stress and Inflammation by Regulating Nrf2/HO-1 and NF-κB Signaling Pathways in Hypoxic-Ischemic Brain Damage in Neonatal Mice. Ann Transl Med. 2022 Jan;10(2):32.

7．Zhang JJ, Li Y, Chen S, Yang XF, Min JW*. Biphalin, a dimeric opioid peptide, reduces neonatal hypoxia-ischemia brain injury in mice by the activation of PI3K/Akt signaling pathway. J Chem Neuroanat. 2021 Sep;115:101967.

8．Liu Y#, Min JW#, Feng S, Subedi K, Qiao F, Mammenga E, Callegari E, Wang H.Therapeutic Role of a Cysteine Precursor, OTC, in Ischemic Stroke Is Mediated by Improved Proteostasis in Mice. Transl Stroke Res. 2020 Feb;11(1):147-160.

9．Min JW, Bu F, Qi L, Munshi Y, Kim GS, Marrelli SP, McCullough LD, Li J. Inhibition of Calcium/Calmodulin-Dependent Protein Kinase Kinase β Is Detrimental in Hypoxia⁻Ischemia Neonatal Brain Injury. Int J Mol Sci. 2019 Apr 26;20(9):2063.

10．Min JW, Liu Y, Wang D, Qiao F, Wang H. The non-peptidic δ-opioid receptor agonist Tan-67 mediates neuroprotection post-ischemically and is associated with altered amyloid precursor protein expression, maturation and processing in mice. J Neurochem. 2018 Feb;144(3):336-347.

11．Min JW, Kong WL, Han S, Bsoul N, Liu WH, He XH, Sanchez RM, Peng BW. Vitexin protects against hypoxic-ischemic injury via inhibiting Ca2+/Calmodulin-dependent protein kinase II and apoptosis signaling in the neonatal mouse brain. Oncotarget. 2017 Apr 11;8(15):25513-25524.

12．Min JW, Lü L, Freeling JL, Martin DS, Wang H. USP14 inhibitor attenuates cerebral ischemia/reperfusion-induced neuronal injury in mice. J Neurochem. 2017 Mar;140(5):826-833.

13．He M#, Min JW#, Kong WL, He XH, Li JX, Peng BW. A review on the pharmacological effects of vitexin and isovitexin. Fitoterapia. 2016 Dec;115:74-85. （ESI高引）

14．Min JW, Hu JJ, He M, Sanchez RM, Huang WX, Liu YQ, Bsoul NB, Han S, Yin J, Liu WH, He XH, Peng BW. Vitexin reduces hypoxia-ischemia neonatal brain injury by the inhibition of HIF-1alpha in a rat pup model. Neuropharmacology. 2015 Dec;99:38-50.

15．Min JW, Peng BW, He X, Zhang Y, Li JX. Gender difference in epileptogenic effects of 2-BFI and BU224 in mice. Eur J Pharmacol. 2013 Oct 15;718(1-3):81-6.

16．Min JW, Liu WH, He XH, Peng BW. Different types of toxins targeting TRPV1 in pain. Toxicon. 2013 Sep; 71:66-75.