
姓名:龚吉红
职位:副教授,硕士生导师 电子邮箱:jihonggong@foxmail.com龚吉红,毕业于华中科技大学,理学博士,现就职于中南民族大学生物医学工程学院,硕士生导师,担任The Innovation life杂志青年编委,参编专著2部。主持多项横纵向研究项目,包括国家自然科学基金青年、面上项目,湖北省自然科学基金项目,武汉知识创新专项等。长期从事神经信号转导分子机制研究,主要运用细胞生物学、生物物理学、分子/生化等实验手段,在生理和病理情况下研究神经系统细胞信号跨膜转导的时空调节机制,研究重点包括神经突触囊泡释放分子机制、神经突触形成与调节机理,神经网络发育调控,药物镇痛机制等。相关研究成果发表于Nat Neurosci、PNAS、EMBO J、Nat Commun、Adv Drug Deliv Rev、BMC Biol等多种国际知名期刊,入选ESI高被引论文1篇,为诊断、治疗重大神经性疾病提供生物学基础。
神经生物学
1. 国家自然科学基金面上项目:黏附分子PTPμ在神经突触形成中作用机制研究(32571143),2026年-2029年,50万元。
2. 国家自然科学基金青年项目:细胞黏附分子EphB6在神经突触形成中的功能机制研究(32200560),2023年-2025年,30万元。
3. 湖北省自然科学基金青年项目:Munc18-1蛋白结构域3a在突触囊泡分泌中的作用机制研究(2022CFB906),2023年-2024年,5万元。
4. 武汉市知识创新专项曙光计划项目:三萜皂苷单体YF-50在鼠脑神经系统中的镇痛分子机制研究,2023年-2025年,10万元。
5. 中央高校基本科研业务费专项青年项目:基底硬度在神经突触形成中的作用机制研究(CZQ22005),2022年-2024年,5万元。
1) Jihong Gong; Ying Lai; Xiaohong Li; Mengxian Wang; Jeremy Leitz; Yachong Hu; Yunxiang Zhang; Ucheor B Choi; Daniel Cipriano; Richard A Pfuetzner; Thomas C Südhof; Xiaofei Yang; Axel T Brunger; Jiajie Diao; C-terminal domain of mammalian complexin-1 localizes to highly curved membranes, Proc Natl Acad Sci U S A, 2016, 113(47): E7590-E7599 (共同第一作者,中科院一区,IF:9.661)
2) Shen Wang; Ucheor B Choi; Jihong Gong; Xiaoyu Yang; Yun Li; Austin L Wang; Xiaofei Yang; Axel T Brunger; Cong Ma; Conformational change of syntaxin linker region induced by Munc13s initiates SNARE complex formation in synaptic exocytosis, EMBO J, 2017, 36(6): 816-829(共同第一作者,中科院一区,IF:9.792)
3) Shen Wang; Yun Li; Jihong Gong; Sheng Ye; Xiaofei Yang; Rongguang Zhang; Cong Ma; Munc18 and Munc13 serve as a functional template to orchestrate neuronal SNARE complex assembly, Nat Commun, 2019, 10(1): 69 (共同作者,中科院一区,IF:12.121)
4) Xianping Wang; Jihong Gong; Le Zhu; Shen Wang; Xiaoyu Yang; Yuanyuan Xu; Xiaofei Yang; Cong Ma; Munc13 activates the Munc18-1/syntaxin-1 complex and enables Munc18-1 to prime SNARE assembly, EMBO J, 2020, 39(16): e103631(共同第一作者,中科院一区,IF:9.889)
5) Jihong Gong; Xianping Wang; Chaoyang Cui; Yuyang Qin; Ziqi Jin; Cong Ma; Xiaofei Yang; Exploring the two coupled conformational changes that activate the Munc18-1/Syntaxin-1 complex, Front Mol Neurosci, 2021, 14: 785696(第一作者,中科院二区,IF: 5.639)
6) Xiaoqiang Mo; Mengxue Liu; Jihong Gong; Ying Mei; Huidan Chen; Huajun Mo; Xiaofei Yang; Jun Li; 1PTPRM Is Critical for Synapse Formation Regulated by Zinc Ion; Front Mol Neurosci. 2022, Mar 21;15:822458(共同第一作者,中科院二区,IF: 5.639)
7)Jihong Gong; Ziqi Jin; Huidan Chen; Juan He; Yiran Zhang; Xiaofei Yang;Super-resolution fluorescence microscopic imaging in pathogenesis and drug treatment of neurological disease, Adv Drug Deliv Rev. 2023 Mar 31:114791 (第一作者,中科院一区,IF: 17.873)
8)Jihong Gong; Changming Zhang; Bo Wu; Zixun Zhang; Zhongyan Zhou; Jiahui Zhu; Han Liu; Yi Rong; Qian Yin; Yating Chen; Rong Zheng; Guangzhong Yang; Xiaofei Yang; Su Chen;Central and peripheral analgesic active components of triterpenoid saponins from Stauntonia chinensis and their action mechanism;Front Pharmacol. 2023 Oct 16:14:1275041 (第一作者,中科院二区,IF: 5.6)
9)Xianping Wang; Jihong Gong; Le Zhu; Huidan Chen; Ziqi Jin; Xiaoqiang Mo; Shen Wang; Xiaofei Yang; Cong Ma; Identification of residues critical for the extension of Munc18-1 domain 3a; BMC Biol. 2023 Jul 13;21(1):158. (共同第一作者,中科院一区,IF: 5.4 )
10) Qing Pei, Qixin Chen, Zhiqi Tian, Le Zhu, Yang Chen, Jihong Gong, Shen Wang, Yijuan Xiang, John S Khamo, Jiaqi Fan, Yi Rong, Yi Yu, Yuyang Qin, Shiping Wu, Youssef Faragalla, Peng Cao, Kai Zhang, Ying Lai, Ling-Gang Wu, Cong Ma, Xiaofei Yang, Jiajie Diao. Munc18 modulates syntaxin phase separation to promote exocytosis. Nat Neurosci. 2026 Feb;29(2):306-314. (共同第一作者,中科院一区,IF:24.8)
11)Jihong Gong; Xiaofei Yang; Cong Ma; Monitoring Synaptic Exocytosis Using a Whole-Cell Patch Clamp Technique, Methods Mol Biol., 2022; 2473:89-100 (书籍)
12) Haowen Liu; Lei Li; Wei Wang; Jihong Gong; Xiaofei Yang; Zhitao Hu; Spontaneous Vesicle Fusion Is Differentially Regulated at Cholinergic and GABAergic Synapses, Cell Rep, 2018, 22(9): 2334-2345.(共同作者,中科院一区,IF:7.815)
13) Zhiqi Tian; Jihong Gong; Michael Crowe; Ming Lei; Dechang Li; Baohua Ji; Jiajie Diao; Biochemical studies of membrane fusion at the single-particle level[J]. Prog Lipid Res, 2019, 73: 92-100.(共同作者,中科院一区,IF:15.083)
14) Yi Yu, Su Chen, Xiaoqiang Mo, Jihong Gong, Chenhong Li, Xiaofei Yang; Accessory and Central alpha-helices of Complexin Selectively Activate Ca2+ Triggering of Synaptic Exocytosis. [J]. Front Mol Neurosci, 2018, 11: 61.(共同作者,中科院二区,IF: 5.639)
15) 阳小飞; 蒋伟; 陈健; 王明明; 龚吉红; 梅颖; 一种用于神经突触形成分析中的细胞共培养方法, 2018-7-13, 中国, ZL201510450630.3(专利)



