李海梅
职位：副教授
邮箱：hmlichem@whu.edu.cn
个人简介
副教授，武汉大学药学院博士后，入选国家博士后创新人才支持计划（“博新计划”），武汉大学“卓越博士后”计划，SmartSys期刊青年编委。主要从事微/纳界面催化、功能纳米材料与器件等研究，为“接触电致催化(CEC)”领域的建立和发展作出突出贡献，率先将CEC催化应用于疾病治疗领域，提出了“接触电动力疗法(CEDT)”概念。主持国家自然科学基金、中国博士后科学基金3项。近五年发表SCI论文30余篇，其中，以第一/通讯作者身份在JACS、Adv Mater、Mater Today、ACS Nano、Biomaterials、Chem Sci、Anal Chem等杂志发表20余篇；申请国家发明专利5项；参编专著1部。
研究方向
1. 生物界面自由基反应调控与疾病治疗
2. 可穿戴/可植入药物递送及健康监测系统
主持项目
1. 国家自然科学基金青年科学基金项目，22403070，全氟化碳纳米乳的抗肿瘤生物活性机制热力学基础，2025/01-2027/12，30万元，在研，主持。
2. 国家博士后创新人才支持计划（“博新计划”），BX20230268，静电击穿脉冲电刺激诱导的免疫微环境调控及CAR-T实体瘤治疗，2023/10-2025/10，68万，已结题，主持。
3. 中国博士后科学基金面上项目，2023M742690，CAR-T细胞膜伪装的荧光纳米酶构建及其实体瘤活体成像与CAR-T治疗应用，2024/01-2025/07，8万元，已结题，主持。
4. 国家自然科学基金面上项目，82473294，基于AI设计的双环肽PROTAC增效CAR-T治疗宫颈癌的作用及机制研究，2025/01-2028/12，48万元，在研，参与。
5. 武汉大学医学实践教学改革研究，2024YB51，药学专业《分析化学实验》教学改革与实践，2023/11-2025/11，1万元，已结题，参与。
代表性成果
1. Haimei Li, Zichen Wang, Xu Chu, Yi Zhao, Guangqin He, Yulin Hu, Yi Liu*, Zhong Lin Wang*, Peng Jiang*. Free radicals generated in perfluorocarbon–water (liquid–liquid) interfacial contact electrification and their application in cancer therapy. J. Am. Chem. Soc., 2024, 146, 12087–12099. (自然指数期刊, 一区TOP, IF=15.6)
2. Ying Yuan#, Haimei Li#, Yuchen Song, Dong Zhang, Zheng Wang, Xinzeyu Yi, Baiwen Qi, Xianzheng Zhang, Peng Jiang*, Aixi Yu*. Drug-free “Triboelectric Immunotherapy” activating immunity for osteomyelitis treatment and recurrence prevention. Adv. Mater., 2024, 2408473. (自然指数期刊, 一区TOP, IF=26.8)
3. Guang-Qin He#, Haimei Li#, Junyi Liu, Yu-Lin Hu, Yi Liu*, Zhong Lin Wang*, Peng Jiang*. Recent progress in implantable drug delivery systems. Adv. Mater., 2024, 36, 2312530. (自然指数期刊, 一区TOP, IF=26.8)
4. Haimei Li, Xiuxiu Yang, Zichen Wang, Wenyan She, Yang Liu, Yi Liu*, Liang Huang*, Peng Jiang*. A near-infrared-II fluorescent nanocatalyst for enhanced CAR T cell therapy against solid tumor by immune reprogramming. ACS Nano, 2023, 17, 11749–11763. (自然指数期刊, 一区TOP, IF=16.0)
5. Haimei Li, Airong Xie, Chengzi Hong, Zichen Wang, Xu Chu, Zhong Lin Wang*, Yi Liu*, Peng Jiang*. Spontaneous hydroxyl radical generation from H2O2 via liquid–liquid contact-electro-catalysis: a hidden catalytic mechanism in contact-electro-dynamic therapy. Chem. Sci., 2025, 16, 20580-20593. (自然指数期刊, 一区TOP, IF=7.5)
6. Haimei Li, Yang Liu, Biao Huang, Caiju Zhang, Zichen Wang, Wenyan She, Yi Liu*, Peng Jiang*. Highly efficient GSH-responsive “off-on” NIR-II fluorescent Fenton nanocatalyst for multimodal imaging-guided photothermal/chemodynamic synergistic cancer therapy. Anal. Chem., 2022, 94, 10470–10478. (自然指数期刊, 一区TOP, IF=6.7)
7. Haimei Li#, Chaoyu Chen#, Zichen Wang, Yiman Huang, Guangqin He, Yi Liu*, Peng Jiang*, Zhong Lin Wang*. Triboelectric immunotherapy using electrostatic-breakdown induced direct-current. Mater. Today, 2023, 64, 40–51. (一区TOP, IF=22.0)
8. Haimei Li, Zichen Wang, Yulin Hu, Guangqin He, Liang Huang, Yi Liu*, Zhong Lin Wang*, Peng Jiang*. Enhancing CAR-T cell therapy against solid tumor by drug-free triboelectric immunotherapy. Biomaterials, 2025, 314, 122871. (一区TOP, IF=12.9)
9. Yuchen Song#, Haimei Li#, Ying Yuan#, Dong Zhang, Zheng Wang, Baiwen Qi, Peng Jiang*, Aixi Yu*. Synergistic photothermal-sonodynamic therapy for antibacterial and immune reprogramming in chronic osteomyelitis. J. Control. Release, 2025, 381, 113612. (一区TOP, IF=11.5)
10. Haimei Li, Yulin Hu, Zichen Wang, Liang Huang, Yi Liu*, Peng Jiang*. Suppression of cytokine release syndrome by conjugating TCR-signaling-responsive siltuximab nanogels with CAR-T Cells. Nano Res., 2025, 18, 94908075. 一区TOP, IF=9.0)
11. Haimei Li#, Yuying Wang#, Yi Liu*, Peng Jiang*. Tumor microenvironment-responsive Cu/CaO2 nanocomposites for amplified pyroptosis and cuproptosis. J. Colloid Interface Sci., 2025, 698, 138044. (一区, IF=9.7)
12. Sichen Zhang, Chengzi Hong, Yulin Hu, Haimei Li*, Peng Jiang*. Self-powered wearable reverse iontophoresis system for interstitial fluid lactate extraction and detection. Nano Energy, 2025, 141, 111119. (二区TOP, IF=17.1)
13. Wenjing Wu#, Haimei Li#, Wenqi Chen, Yulin Hu, Zichen Wang, Wenyan She, Liang Huang*, Yi Liu*, Peng Jiang*. CAR T cell membrane camouflaged nanocatalyst augments CAR T cell therapy efficacy against solid tumor. Small, 2024, 2401299. (二区TOP, IF=12.1)
14. Haimei Li#, Guangqin He#, Yulin Hu, Peng Jiang*. Ultrasound wirelessly controlled electrically responsive implantable drug delivery system for enhanced tumor therapy. Small, 2025, 2412704. (二区TOP, IF=12.1)
15. Yu-Lin Hu#, Haimei Li#, Guang-Qin He, Peng Jiang*. Immunotherapy/calcium electroporation system for synergistically enhanced tumor therapy. Small, 2025, 2411121. (二区TOP, IF=12.1)
16. Haimei Li, Zichen Wang, Yi Liu*, and Peng Jiang*. Visible/NIR-II ratiometric fluorescence imaging for tissue depth analysis. ACS Appl. Nano Mater., 2024, 7, 28573-28581. (二区, IF=5.3)
17. Haimei Li, Yiman Huang, Yi Liu*, Peng Jiang*. Thermodynamics, conformation and biocatalytic performance of glucose oxidase combined with black phosphorus quantum dots. Langmuir, 2023, 39, 334–342. (二区, IF=3.7)
18. Haimei Li, Yaofa Liu, Shulan Li, Silong Zhang, Biao Huang, Ran Cui, Yi Liu*, Peng Jiang*. Cu-doped black phosphorus quantum dots as multifunctional Fenton nanocatalyst for boosting synergistically enhanced H2O2-guided and photothermal chemodynamic cancer therapy. Nanoscale, 2022, 14, 3788–3800. (三区, IF=5.8)
