出生年月：1971.08
民族：汉族
职称：教授
学科专业：微生物与生化药学、药物化学、生药学、生物信息学、药物分析学
研究方向：
1、微生物天然产物的生物合成途径解析；
2、新颖骨架与抗菌活性的天然产物分离鉴定；
3、结构生物学与酶工程改造；
4、基于深度学习的天然产物挖掘；
电子邮箱:hdengabdn@gmail.com
ORCID主页：https://orcid.org/0000-0002-0047-0622
教育及工作经历
2026.07 –至今，中南民族大学，药学院，教授
2022.08 – 2026.06，英国阿伯丁大学化学系，教授（Chair，终生教职）
2021.12 – 2023.10，上海交通大学医学院，访问教授（Visiting Professor，兼职）
2021.10 – 2024.10，英国阿伯丁大学化学系，副系主任（科研）（Director of Research）
2018.08 – 2022.07，英国阿伯丁大学化学系，READER（终生教职）
2014.08 – 2018.07，英国阿伯丁大学化学系，高级讲师 （Senior Lecturer，终生教职）
2008.10 – 2014.07，英国阿伯丁大学化学系，讲师 （Lecturer,终生教职）
2002.06 – 2008.09，英国圣安德鲁斯大学化学学院，博士后
1999.01 – 2002.06，英国威尔士斯旺斯大学，化学生物工程学院，理科博士
1995.09 – 1998.07，华中科技大学，化学系高分子化学专业，化学理科硕士
1989.09 – 1993.07，华南理工大学，高分子化工系高分子化工专业，工学学士
主要荣誉奖励
英国皇家化学学会会士（Fellow of Royal Society of Chemistry，FRSC）
学术和社会兼职
·英国创新署(UKRI)会评专家组成员（Panel Member）；
·英国创新署人才创新计划专家学院（UKRI Talent Peer Review College（PRC））成员；
·英国生物技术与生物科学研究创新计划（Pioneer Awards assessment）会评专家组成员；
·英国创新署生物技术与生物科学研究理事会专家池成员（Pool of Expert）（2020-2024）；
·英国创新署自然科学研究理事会（EPSRC）同行评议学院成员（Peer Review College）；
·英国创新署，Wellcome Trust和Leverhulme Trust,苏格兰资助委员会（Scottish Funding Council）IBioIC研发中心,德国葡萄牙科学与技术基金会（FCT）,卡塔尔基金委（QNRF） 和加拿大魁北克科学与技术基金会的涵评评审专家；
·国际会议系列Directing Biosynthesis Online组织委员会成员和分会主持；
近五年主持科研项目情况
1.苏格兰皇家学会-台湾省国家科学及技术委员会合作交流项目，£11,790，2026.03-2028.02，主持；
2.欧盟委员会玛丽居里博士后奖学金（Marie Skłodowska-Curie Actions Postdoctoral Fellowships），€260,348，2025.06-2027.05，主持；
3.英联邦奖学金（Commonwealth Scholarships），£69,000，2024.10-2027.09，主持；
4.尼日利亚TETFUND，£88,000，2023.02-2026.01，主持；
5.英国皇家学会-中国自然科学基金委合作交流项目，£11810，2022.04-2024.03，主持；
6.苏格兰皇家学会-中国自然科学基金委合作交流项目，£11,760，2021.04-2023.03，主持；
7.中国自然科学基金委海外及港澳学者合作研究基金延续项目，¥160万，2020.01-2023.12，主持；
8.苏格兰资助委员会IBioIC研发中心，£109,328，2019.10-023.09，主持；
9.英国皇家学会-中国自然科学基金委合作交流项目，£11,800，2018.04-2020.03，主持；
10.英国创新署生物技术与生物科学研究理事会（BBSRC），£494,220，2018.02-2021.09，主持；
11.英国沙特阿拉伯文化署（Saudi Arabic Cultural Mission），£74,700，主持；
12.英国创新署生物技术与生物科学研究理事会（BBSRC），£96,981，2017.12-2022.05，主持；
13.英国创新署生物技术与生物科学研究理事会（BBSRC），£526,886，2017.04-2021.07，主持；
近年来论文发表情况
目前，在国际知名学术期刊上发表SCI收录论文及专著章节共计105篇包括Nature,Chem. Rev.,Nat. Chem. Biol.,Nat. Comm.,Angew. Chemie. Int. Ed.,Chem. Sci.,Cur. Op. Chem. Biol.,J. Biol.Chem.,Nat. Prod. Rep., Chem. Comm, Cell Chem.Biol.等。
部分代表性论文如下（按时间倒序）：
1.Shan Wang#*, Kewen Wu#, Ya Jie Tang*,Hai Deng*, Dehydroamino acid residues in bioactive natural products,Natural Product Reports, 2024, 41, 273-297.
2.Fleurdeliz Maglangit, Shan Wang, Arvin Moser, Kwaku Kyeremeh, Laurent Trembleau, Yongjun Zhou, David James Clark, Jioji Tabudravu*,Hai Deng*, Accraspiroketides A-B, phenylnaphthacenoid-derived polyketides with unprecedented [6 + 6+6 + 6] + [5 + 5] spiro-architecture,Journal of Natural Products, 2024, 87, 831-836.
3.Li Su,Hai Deng*, Size matters,Nature Chemical Biology, 2024, 20, 8-10.
4.Federica Casolari, Saad Alrashdi, Reuben Carr,Hai Deng*, Exploring a Streptomyces wax synthase using acyl-SNACs as donor substrates,RSC Chemical Biology, 2023, 4, 742-747.
5.Shan Wang#, Sixing Lin#, Qing Fang, Roland Gyampoh, Zhou Lu, Yingli Gao, David J. Clarke, Kewen Wu, Laurent Trembleau, Yi Yu*, Kwaku Kyeremeh*, Bruce F. Milne*, Jioji Tabudravu*,Hai Deng*, A ribosomally synthesised and post-translationally modified peptide containing a β-enamino acid and a macrocyclic motif,Nature Communications, 2022, 13, 5044.
6.Shan Wang#, William D. G. Brittain#, Qian Zhang#, Zhou Lu, Ming Him Tong, Kewen Wu, Kwaku Kyeremeh, Matthew Jenner*, Yi Yu*, Steven L. Cobb*,Hai Deng*, Aminoacyl chain translocation catalysed by a type II thioesterase domain in an unusual non-ribosomal peptide synthetase,Nature Communications, 2022, 13, 62.
7.Shan Wang*,Hai Deng*, Peculiarities of promiscuous L-threonine transaldolases for enantioselective synthesis of β-hydroxy-α-amino acids,Applied Microbiology and Biotechnology, 2021, 105, 3507-3520.
8.Shan Wang#*, Qing Fang#, Zhou Lu, Yingli Gao, Laurent Trembleau, Rainer Ebel, Jeanette H. Andersen, Carol Philips, Samantha Law,Hai Deng*, Discovery and biosynthetic investigation of a new antibacterial dehydrated non-ribosomal tripeptide,Angewandte Chemie International Edition, 2021, 60, 3229-3237.
9.Fleurdeliz Maglangit*, Yi Yu*,Hai Deng*, Bacterial pathogens: threat or treat (a review on bioactive natural products from bacterial pathogens),Natural Product Reports, 2021, 38, 782-821.
10.Qing Fang, Linrui Wu, Caroline Urwald, Morgane Mugat, Shan Wang, Kwaku Kyeremeh, Carol Philips, Samantha Law, Yongjun Zhou,Hai Deng*, Genomic scanning enabling discovery of a new antibacterial bicyclic carbamate-containing alkaloid,Synthetic and Systems Biotechnology, 2021, 6, 12-19.
11.Linrui Wu, Ming Him Tong, Andrea Raab, Qing Fang, Shan Wang, Kwaku Kyeremeh, Yi Yu,Hai Deng*, An unusual metal-bound 4-fluorothreonine transaldolase fromStreptomycessp. MA37 catalyses promiscuous transaldol reactions, Applied Microbiology and Biotechnology, 2020, 104, 3885-3896.
12.Linrui Wu, Fleurdeliz Maglangit,Hai Deng*, Fluorine biocatalysis,Current Opinion in Chemical Biology, 2020, 55, 119-126.
13.Yating Liu#, Li Su#, Qing Fang, Jioji Tabudravu, Xiaohui Yang, Kirstie Rickaby, Laurent Trembleau, Kwaku Kyeremeh, Zixin Deng,Hai Deng*, Yi Yu*, Enzymatic reconstitution and biosynthetic investigation of the bacterial carbazole neocarazostatin A,The Journal of Organic Chemistry, 2019, 84, 16323-16328.
14.Yongjun Zhou, Xiao Lin, Chunmin Xu, Yaoyao Shen, Shu Ping Wang, Hongze Liao, Lei Li,Hai Deng*, HouWen Lin*, Investigation of penicillin binding protein (PBP)-like peptide cyclase and hydrolase in surugamide non-ribosomal peptide biosynthesis,Cell Chemical Biology, 2019, 26, 737-744.e734.
15.Bin Wang#, Xuejie Li#, Dou Yu, Xiaoyi Chen, Jioji Tabudravu,Hai Deng*, Li Pan*, Deletion of the epigenetic regulator GcnE inAspergillus nigerFGSC A1279 activates the production of multiple polyketide metabolites,Microbiological Research, 2018, 217, 101-107.
16.Bin Wang#, Yangyong Lv#, Xuejie Li, Yiying Lin,Hai Deng, Li Pan*, Profiling of secondary metabolite gene clusters regulated by LaeA inAspergillus nigerFGSC A1279 based on genome sequencing and transcriptome analysis,Research in Microbiology, 2018, 169, 67-77.
17.Sheng Huang, Jioji Tabudravu, Somayah S. Elsayed, Jeanne Travert, Doe Peace, Ming Him Tong, Kwaku Kyeremeh, Sharon M. Kelly, Laurent Trembleau, Rainer Ebel, Marcel Jaspars, Yi Yu*,Hai Deng*, Discovery of a single monooxygenase that catalyzes carbamate formation and ring contraction in the biosynthesis of the Legonmycins,Angewandte Chemie International Edition, 2015, 54, 12697-12701.
18.Sheng Huang, Somayah S. Elsayed, Meinan Lv, Jioji Tabudravu, Mostafa E. Rateb, Roland Gyampoh, Kwaku Kyeremeh, Rainer Ebel, Marcel Jaspars, Zixin Deng, Yi Yu*,Hai Deng*, Biosynthesis of neocarazostatin a reveals the sequential carbazole prenylation and hydroxylation in the Tailoring Steps,Chemistry & Biology, 2015, 22, 1633-1642.
19.Long Ma, Axel Bartholomé, Ming Him Tong, Zhiwei Qin, Yi Yu, Thomas Shepherd, Kwaku Kyeremeh,Hai Deng*, David O'Hagan*, Identification of a fluorometabolite fromStreptomyces sp.MA37: (2R3S4S)-5-fluoro-2,3,4-trihydroxypentanoic acid,Chemical Science, 2015,6, 1414-1419.
20.David O'Hagan,Hai Deng*, Enzymatic fluorination and biotechnological developments of the fluorinase,Chemical Reviews, 2015, 115, 634-649.
21.Zhiwei Qin, Alexander Thomas Baker, Andrea Raab, Sheng Huang, Tiehui Wang, Yi Yu, Marcel Jaspars, Christopher J. Secombes*,Hai Deng*, The fish pathogenYersinia ruckeriproduces holomycin and uses an RNA methyltransferase for self-resistance,The Journal of Biological Chemistry, 2013, 288, 14688-14697.
22.Sheng Huang, Yudong Zhao, Zhiwei Qin, Xiaoling Wang, Mayca Onega, Li Chen, Jing He, Yi Yu*,Hai Deng*, Identification and heterologous expression of the biosynthetic gene cluster for holomycin produced byStreptomyces clavuligerus,Process Biochemistry, 2011, 46, 811-816.
23.Hai Deng, Catherine H. Botting, John T. G. Hamilton, Rupert J. M. Russell, David O'Hagan*, S-adenosyl-L-methionine: hydroxide adenosyltransferase: a SAM enzyme,Angewandte Chemie International Edition, 2008, 47, 5357-5361.
24.Hai Deng, Stuart M. Cross, Ryan P. McGlinchey, John T. G. Hamilton, David O'Hagan*, In vitro reconstituted biotransformation of 4-fluorothreonine from fluoride ion: application of the fluorinase,Chemistry & Biology, 2008, 15, 1268-1276.
25.Hai Deng,David O'Hagan*, The fluorinase, the chlorinase and the duf-62 enzymes,Current Opinion in Chemical Biology, 2008, 12, 582-592.
26.Hai Deng, Steven L. Cobb, Andrew R. McEwan, Ryan P. McGlinchey, James H. Naismith, David O'Hagan*, David A. Robinson, Jonathan B. Spencer, The fluorinase fromStreptomyces cattleyais also a chlorinase,Angewandte Chemie International Edition, 2006, 45, 759-762.
27.Hai Deng, Steven L. Cobb, Antony D. Gee, Andrew Lockhart, Laurent Martarello, Ryan P. McGlinchey, David O'Hagan*, Mayca Onega, Fluorinase mediated C-(18)F bond formation, an enzymatic tool for PET labelling,Chemical Communications, 2006, DOI: 10.1039/b516861a, 652-654.
28.Hai Deng, David O'Hagan*, Christoph Schaffrath, Fluorometabolite biosynthesis and the fluorinase fromStreptomyces cattleya,Natural Product Reports, 2004, 21, 773-784.
29.Changjiang Dong, Fanglu Huang,Hai Deng, Christoph Schaffrath, Jonathan B. Spencer, David O'Hagan, James H. Naismith*, Crystal structure and mechanism of a bacterial fluorinating enzyme,Nature, 2004, 427, 561-565.
