
出生年月:1994.11
民族:汉族
职称:特聘副研究员
学科专业:微生物与生化药学、结构生物学、生药学
研究方向:天然产物生物合成途径与酶功能机制解析
电子邮箱:qianzhang_lab@163.com
ORCID主页:https://orcid.org/0000-0002-5814-5435
教育及工作经历
2026.07-至今, 中南民族大学,药学院,特聘副研究员
2023.01-2026.06,武汉大学,药学院,博士后
2017.09-2022.12,武汉大学,药学院,博士(硕博连读),理学博士
2022.03-2022.09,英国牛津大学,短期访问研究生
2018.10,英国阿伯丁大学化学系,短期访问研究生
2013.09-2017.06,华中农业大学,生命科学技术学院,工学学士
荣誉奖励
1.2023年度国家资助博士后研究人员计划B类资助(“博新计划”入会评),资助编号:GZB20230548
2.2023年度武汉大学-中国光谷奖学金;
3.2022年度博士研究生国家奖学金;
承担科研项目情况
1.国家自然科学基金青年项目,82304356,4-氨基葡萄糖的生物合成机制解析助力新型抗菌药物研发,30万,2024.01-2026.12,主持,在研;
2.中国博士后科学基金第74批面上资助,2023M742710,基于苯并噁唑环生物合成机制定向智造苯并杂环先导药物,8万,2023.12-2025.06,主持,结题;
3.湖北省博士后创新研究岗位:基于化学酶工程定向生物智造新型苯并杂环先导药物,6万,2023.11-2024.12,主持,结题;
4.武汉大学“临床医学+X青年拔尖项目"面上项目,2042025YXB013,氨基酸感受器GATOR2在牙周炎衰老信息传递中的作用研究,10万,2025.01-2025.12,合作参与;
发表论文情况
1.Qian Zhang#, Yixin Zhang#, Yuting Cui, Zixin Deng, Feng Long*, Yi Yu*, Phosphate-taggedsubstraterecognition by a PrmC-likemethyltransferase inapramycinbiosynthesis,International Journalof Biological Macromolecules,2026, 372, 153063.(IF=8.7,二区top)
2.Qian Zhang,Yixin Zhang, Zixin Deng, Yi Yu*.A KAS III-likeenzyme and anamidohydrolase innataxazolebiosynthesisdirectformation of thebenzoheterocyclemoiety.ACS Catalysis2025, 15(9), 7079-7092. (IF=13.6,一区top)
3.Shan Wang#, Will D. G. Brittain#,Qian Zhang#, Zhou Lu, Ming Him Tong, Kewen Wu, Kwaku Kyeremeh, Matthew Jenner*, Yi Yu*, Steven L Cobb*, Hai Deng*.Aminoacylchaintranslocationcatalysed by atype IIthioesterasedomain in anunusualnon-ribosomalpeptidesynthetase.Nature Communications,2022,13(1):62.(IF=18.1,#co-first author,一区top)
4.Linrui Wu#,Qian Zhang#, Zixin Deng, Yi Yu*.From solo to duet, intersections of natural product assembly with self-resistance.Natural Product Reports, 2022, 39, 919-925.(IF=12.5,#co-first author,一区top)
5.Qian Zhang, Chang He, Jing Sun, Yi Yu*.N-7′ methylation in apramycin: its biosynthesis and biological role,Organic Chemistry Frontiers, 2022, 9, 2708-2713.(IF=4.5,一区)
6.Qian Zhang#, Hao-Tian Chi#, Linrui Wu, Zixin Deng, Yi Yu*. Twocrypticself-resistancemechanisms inStreptomyces tenebrariusrevealinsights into thebiosynthesis ofapramycin.Angewandte Chemie International Edition, 2021, 60(16):8990-8996.(IF=17.6,一区top)
7.Xuan Yun#,Qian Zhang#, Meinan Lv#, Hai Deng, Zixin Deng, Yi Yu*.In vitro reconstitution of the biosynthetic pathway of 3-hydroxypicolinic acid.Organic & Biomolecular Chemistry, 2019, 17(3):454-460.(IF=2.8,#co-first author)
8.Darwin Linardi, Weiyi She,Qian Zhang, Yi Yu, Pei-Yuan Qian and Herry Lam*.Proteomining-basedelucidation ofnaturalproductbiosyntheticpathways inStreptomyces,Frontiers in Microbiology, 2022, 13, 913756. (IF=5.8,二区top)
9.LarissaKever,Qian Zhang,Aël Hardy,Philipp Westhoff, Yi Yu,Julia Frunzke*.Resistance against aminoglycoside antibiotics via drug or target modification enables community-wide antiphage defense.microLife,2024, 5, uqae015.
10.林思行,虞沂,张倩*.核糖体合成和翻译后修饰肽graspetide类天然产物的研究进展[EB/OL].北京:中国科技论文在线[2023-05-10].
11.赵钦,韩月,季耀庭,曲书苑,张倩,一种二氧化铈纳米药物递送系统及其制备方法和应用(公开号:CN120678946A),发明专利,中国。