尹荣华

发布时间:2020-11-27 浏览次数:

个人信息:

姓名:尹荣华

出生年月:1990-10

民族:汉

学科专业:药物化学

电子邮箱:yinronghua2017@outlook.com

 

教育及工作经历:

2020.9—至今  中南民族大学药学院,讲师

2019.1—2020.9  中国科学院昆明植物研究所,助理研究员

2015.9—2019.1 中国科学院昆明植物研究所,理学博士

2012.9—2015.6 中国科学院昆明植物研究所,理学硕士

2008.9—2012.6  四川农业大学,农学学士

 

研究方向:

天然产物糖化学及基于结构片段的活性评价与新药研发

 

科研项目:

1. 二糖侧链FG的确切结构特征及其对FXase抑制活性的影响研究,国家自然科学基金青年基金项目, 2020.1-2022.12年,25万,主持;

2. FG-8mer抑制内源性因子X酶的分子机制及其机制相关的抗凝活性特征,国家自然科学基金面上项目, 2018.1-2021.1256万,参加;

3. 内源性F.Xase抑制剂LFG-53新药临床前研究,中国科学院药物创新研究院自主部署科研项目,2015.9-2017.8192.5万,参加。

代表性论文:

1. Ronghua Yin, Lutan Zhou, Na Gao, Zi Li, Longyan Zhao, Feineng Shang, Mingyi Wu*, Jinhua Zhao*, Oligosaccharides from depolymerized fucosylated glycosaminoglycan: structures and minimum size for intrinsic factor Xase complex inhibition, Journal of Biological Chemistry. 2018, 293:14089-14099.

2. Ronghua Yin, Zhenzhu Zhao, Heping Chen, Xia Yin, Xu Ji, Zejun Dong, Zhenghui Li, Tao Feng*, Jikai Liu*, Tremulane sesquiterpenes from cultures of the fungus Phellinus igniarius and their vascular-relaxing activities, Phytochemistry Letters. 2014, 10:300-303.

3. Ronghua Yin, Zhenzhu Zhao, Xu Ji, Zejun Dong, Zhenghui Li, Tao Feng*, Jikai Liu*, Steroids and sesquiterpenes from cultures of the fungus Phellinus igniarius, Natural Products and Bioprospecting. 2015, 5:17-22.

4. Ronghua Yin, Xue Bai, Tao Feng, Zejun Dong, Zhenghui Li*, and Jikai Liu*, Two new compounds from Xanthium strumarium, Journal of Asian Natural Products Research. 2016, 18: 354-359.

5. Ying Cai1, Wenjiao Yang1, Xiaomei Li, Lutan Zhou, Zhongjuan Wang, Lisha Lin, Dingyuan Chen, Longyan Zhao, Zhongkun Li, Shubai Liu, Ronghua Yin*, Zhili Zuo*, Na Gao*, Jinhua Zhao, Precise structures and anti-intrinsic tenase complex activity of three fucosylated glycosaminoglycans and their fragments, Carbohydrate Polymers. 2019, 224:115146.

6. Zhicheng He, Lutan Zhou, Lisha Lin, Ronghua Yin*, Jinhua Zhao*, Structure and heparanase inhibitory activity of a new glycosaminoglycan from the slug Limacus flavus, Carbohydrate Polymers. 2019, 220:176-184.

7. Wenqi Zheng, Lutan Zhou, Lisha Lin, Ying Cai, Huifang Sun, Longyan Zhao, Na Gao, Ronghua Yin* Jinhua Zhao*, Physicochemical characteristics and anticoagulant activities of the polysaccharides from sea cucumber Pattalus mollis, Marine Drugs. 2019, 17:198.

8. Wenjiao Yang1, Dingyuan Chen1, Zhicheng He, Lutan Zhou, Ying Cai, Hui Mao, Na Gao*, Zhili Zuo*, Ronghua Yin*, Jinhua Zhao, Precise structure and anticoagulant activity of β-eliminative depolymerized fucosylated glycosaminoglycan from Holothuria coluber, Carbohydrate Polymers. 2020, 233:115844.

9. Feineng Shang1, Na Gao1, Ronghua Yin, Lisha Lin, Chuang Xiao, Lutan Zhou, Zi Li, Steven W. Purcell, Mingyi Wu*, Jinhua Zhao*, Precise structures of fucosylated glycosaminoglycan and its oligosaccharides as novel intrinsic factor Xase inhibitors, European Journal of Medicinal Chemistry. 2018, 148: 423-435.

10. Wenjiao Yang, Ying Cai, Ronghua Yin, Lisha Lin, Zhongkun Li*, Mingyi Wu*, Jinhua Zhao*, Structural analysis and anticoagulant activities of two sulfated polysaccharides from the sea cucumber Holothuria coluber, International Journal of Biological Macromolecules. 2018, 115: 1055-1062.

11. Ying Cai, Wenjiao Yang, Ronghua Yin, Lutan Zhou, Zhongkun Li*, Mingyi Wu*, Jinhua Zhao*, An anticoagulant fucan sulfate with hexasaccharide repeating units from the sea cucumber Holothuria albiventer, Carbohydrate Research, 2018, 464:12-18.

12. Lisha Lin, Longyan Zhao, Na Gao, Ronghua Yin, Sujuan Li, Huifang Sun, Lutan Zhou, Guiling Zhao, Steven W. Purcell, Jinhua Zhao*, From multi-target anticoagulants to DOACs, and intrinsic coagulation factor inhibitors, Blood Reviews. 2020, 39:100615.

13. Heping Chen, Zhenzhu Zhao, Ronghua Yin, Xia Yin, Tao Feng, Zhenghui Li, Kun Wei, Jikai Liu, Six new vibralactone derivatives from cultures of the fungus Boreostereum vibrans, Natural Products and Bioprospecting. 2014, 4:271-276.

14. Dongbao Hu, Wenxin Li, Zhenzhu Zhao, Tao Feng, Ronghua Yin, Zhenghui Li, Jikai Liu*, Huajie Zhu*, Highly unsaturated pyranone derivatives from the basidiomycete Junghuhnianitida, Tetrahedron Letters. 2014, 55:6530-6533.

15. Jiangbo He, Xiaoman Lv, Zhenghui Li, Shen Zhang, Dongbao Hu, Ronghua Yin, Zhenzhu Zhao, Tao Feng*, Jikai Liu*, Chain terpenoids isolated from cultures of basidiomycete Phellinus sp. Journal of Asian Natural Products Research. 2015, 17:1-5.

 

 

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