尹世金

发布时间:2019-10-22 浏览次数:

出生年月:19749月

民族:汉族

职称:教授

学科专业:基因工程制药与离子通道药理学

研究方向:以疾病相关性离子通道蛋白为靶点,综合运用基因工程制药、有机小分子合成、膜片钳电生理实验、免疫组织化学及计算机辅助药物设计等技术,进行生物活性多肽和有机小分子的研发,从分子、细胞和模型动物水平筛选具有潜在药用价值的先导化合物。

电子邮箱:yinshijinyf@163.com


简 历

学习和研究经历:

1993.9-1998.7武汉大学医学院五年制临床医学系学习,获临床医学学士学位;

1998.9-2001.7武汉大学医学院攻读并获神经生理学硕士学位;

2001.7-至今 中南民族大学任教,现为教授职称,化学生物学系主任;

2006.9-2009.6武汉大学生命科学院获微生物学博士学位;

2011.6-2014.5在美国德克萨斯州立大学医学院药理学系从事博士后研究工作;

2014.5-2014.8 在美国圣路易斯华盛顿大学医学院麻醉系从事博士后研究工作。


一、主持和参与的省部级研究项目:

1、国家自然科学基金应急管理项目,81641186龙血竭中的Kv1.3阻断剂及其自身免疫调节作用、2017/01-2017/12、10万元、在研、主持。

2、国家自然科学基金面上项目,81373379中国蜈蚣目物种多样性调查及药用物种转录组学研究、2014/01-2017/12、70万元、在研、主持。

3、湖北省自然科学基金面上项目,2015CFB491、龙血竭治疗自身免疫疾病的机制研究、2015.4~2017.4、3万元、在研、主持。

4、湖北省自然科学基金,BZY12010、利用生物信息二级数据库开发蛋白质结构网络研究平台、2012/11-2014/11、5万元、已结题、参加。

5、广东省科技厅产学研结合项目,010B090400047、嵌入式无线网络在ICU临床信息系统的应用、2010/10-2013/06、30万元、已结题、主持。

6、国家自然科学青年基金项目,30900239、BmαTX14多肽与通道β亚基协同调节钠通道功能的机制研究、2010/01-2012/12、20万元、已结题、主持。

7、国家自然科学青年基金项目,30900265、钾通道KCNQ1孔区外庭的结构特征与功能研究、2010/01-2012/12、20万元、已结题、参加。

8、湖北省自然科学基金,BZZ03001、血竭薄膜衣片的研究、2003/06,已结题、参加。


二、发表的代表性研究论文:

(1) Kim S, Barry DM, Liu XY, Shijin Yin,et al. Facilitation of TRPV4 by TRPV1 is required for itch transmission in some sensory neuron populations.Sci Signal, 2016, 9(437):ra71.(SCI1, IF 7.359)

(2) Shijin YinYanning QiuZhaohui PanShaobin LiZhiyong Di . Chaerilus pseudoconchiformus sp. nov., a new species found in Xizang, and an updated key of the chaerilid scorpions from China (Scorpiones:Chaerilidae)ZooKeys201549541-51.SCI

(3) Shijin YinYunfeng ZhangZhaohui PanShaobin LiZhiyong Di Scorpiops ingens sp.nov.,found in Xizang, and an updated key of Scorpions from China(Scorpiones:Euscorpidae, Scorpiopinae)ZooKeys201549553-61SCI

(4) Kimball C, Luo J, Shijin Yin, Hu H, Dhaka A.The Pore Loop Domain of TRPV1 Is Required for Its Activation by the Volatile Anesthetics Chloroform and Isoflurane. Mol Pharmacol, 2015, 88(1):131-8.SCI, IF 3.931

(5) Shijin YinQinglan HuJialie LuoYuxin LiChunlan LuXuanChenHongzhen Hu. Loureirin B, an essential component of Sanguis Draxonis,inhibits Kv1.3 channel and suppresses cytokine release from Jurkat T cellsCell & Bioscience2014478。(SCI, 通讯作者

(6) Shijin,Yin, Jialie Luo, Aihua Qian, Weihua Yu, Hongzhen Hu. LE135, a retinoid acid receptor antagonist, produces pain through direct activation of TRP channels. Br J Pharmacol. 2014,171(6):1510-20 (SCI 2区,IF 5.06, 通讯作者)

(7) Shijin,Yin, Jialie Luo, Aihua Qian, Junhui Du, Qing Yang, Shentai Zhou, Weihua Yu, Guangwei Du, Richard B. Clark, Edgar T. Walters, Susan M. Carlton, and Hongzhen Hu. Retinoids activate the irritant receptor TRPV1 and produce sensory hypersensitivity. The Journal of Clinical Investigation, 2013, 8:1-11 (SCI1, IF 12.86)

(8) Feng J, Hu Y, Yi H, Shijin Yin, Han S, Hu J, Chen Z, Yang W, Cao Z, De Waard M, Sabatier JM, Li W, Wu Y. Two conserved arginine residues from the SK3 potassium channel outer vestibule control selectivity of recognition by scorpion toxins. J Biol Chem. 2013, 288(18):12544-53. (SCI 2, IF 5.7)

(9) Dai, Hui1Shijin Yin1Li, TianCao, ZhijianJi, YonghuaWu, YingliangLi, Wenxin. Recombinant expression, purification, and characterization of scorpion toxin Bm alpha TX14. Protein Expression and Purification, 2012,82(2): 325-331.(SCI, 共同第一作者)

(10) Na Gao, Jialie Luo, Karen Uray, Aihua Qian, Shijin Yin, Guodu Wang, Xiyu Wang, Yun Xia,Jackie D. Wood, Hongzhen Hu. CaMKII Is Essential for the Function of the Enteric Nervous System. PLoS One.2012;7(8):1-10.SCI, IF 4.351

(11) Chen Z,Hu Y,Han S,Shijin Yin,He Y,Wu Y,Cao Z,Li W. ImKTx1, a new Kv1.3 channel blocker with a unique primary structure. J Biochem Mol Toxicol.2011 ;25(4):244-51.(SCI)

(12) Song Han1, Shijin Yin1, Hong Yi. Ste´phanie Mouhat, Su Qiu, Zhijian Cao, Jean-Marc Sabatier, Yingliang Wu, and Wenxin Li. Protein-Protein Recognition Control by ModulatingElectrostaticInteractions. J Proteome Res, 2010, 9(6):3118-25SCI 2, IF 5.684, 共同第一作者

(13) Di Z., Cao Z, Wu Y.,Shijin Yin., Gregory D and Li W. Discovery of the centipede family Plutoniumidae(Chilopoda) in Asia: a new species of Theatops from China, and the taxonomic value of spiracle distributions in Scolopendromorpha. Zootaxa, 2010, 2667:51-63.SCI

(14) Liu, J., Ma, Y., Shijin Yin., Zhao, R., Fan, S., Hu, Y., Wu, Y., Cao, Z., Li, W.,. Molecular cloning and functional identification of a new K(+) channel blocker, LmKTx10, from the scorpion Lychas mucronatus. Peptides, 2009, 30(4):675-80. (SCI)

(15) Shijin Yin., Jiang L., Yi H., Han S., Yang D.W., Liu M.L., Liu H., Cao Z.J., Wu Y.L. & Li W.X. Different Residues in Channel Turret Determining the Selectivity of ADWX-1 Inhibitor Peptide between Kv1.1 and Kv1.3 Channels. J Proteome Res,2008, 7, 4890-4897.(SCI 2, IF 5.67)

(16) Shijin Yin; Hong, Y.; Yibao, M.; Zongyun, C.; Han, S.; Yingliang, W.; Zhijian, C.; Wenxin, L., Characterization of a new Kv1.3 channel-specific blocker, J123, from the scorpion Buthus martensii Karsch. Peptides, 2008299: 1514-20. (SCI)

(17) Han, S1.; Yi, H1.; Shijin Yin1.; Chen, Z. Y.; Liu, H.; Cao, Z. J.; Wu, Y. L.; Li, W. X., Structural basis of a potent Peptide inhibitor designed for kv1.3 channel, a therapeutic target of autoimmune disease. J Biol Chem , 2008, 283, 19058-19065.(SCI 2, IF 5.7, 共同第一作者)

(18) Liu, Z.; Liu, W.; Xiao, Z.; Wang, G.; Shijin Yin.; Zhu, F.; Wang, H.; Cheng, J.; Wang, X.; He, X.; Li, W., A major single nucleotide polymorphism of the PDLIM5 gene associated with recurrent major depressive disorder. J Psychiatry Neurosci, 2008, 33, 43-46.(SCI)

(19) Wu, W1.; Shijin Yin1.; Ma, Y.; Wu, Y. L.; Zhao, R.; Gan, G.; Ding, J.; Cao, Z.; Li, W., Molecular cloning and electrophysiological studies on the first K(+) channel toxin (LmKTx8) derived from scorpion Lychas mucronatus. Peptides, 2007, 28, 2306-2312.SCI, 共同第一作者

(20) Yi, H.; Cao, Z.; Shijin Yin.; Dai, C.; Wu, Y.; Li, W., Interaction simulation of hERG K+ channel with its specific BeKm-1 peptide: insights into the selectivity of molecular recognition. J Proteome Res, 2007, 6, 611-620. (SCI, IF 5.67)

(21) Mao, X.; Cao, Z.; Shijin Yin.; Ma, Y.; Wu, Y.; Li, W., Cloning and characterization of BmK86, a novel K+ -channel blocker from scorpion venom. Biochem Biophys Res Commun, 2007, 360, 728-734.(SCI)

(22) Zhijian, C.; Yun, X.; Chao, D.; Shunyi, Z.; Shijin Yin.; Yingliang, W.; Wenxin, L., Cloning and characterization of a novel calcium channel toxin-like gene BmCa1 from Chinese scorpion Mesobuthus martensii Karsch. Peptides, 2006, 27, 1235-1240. (SCI

(23) Zhijian, C.; Chao, D.; Shijin Yin.; Yingliang, W.; Jiqun, S.; Yonggang, S.; Wenxin, L., Splicing of scorpion toxin gene BmKK2 in HEK 293T cells. J Biochem Mol Toxicol, 2006, 20, 1-6.(SCI)

(24) Wang, K.;Shijin Yin; Lu, M.; Yi, H.; Dai, C.; Xu, X. J.; Cao, Z. J.; Wu, Y. L.; Li, W. X., Functional analysis of the alpha-neurotoxin, BmalphaTX14, derived from the Chinese scorpion, Buthus martensii Karsch. Biotechnol Lett, 2006, 28, 1767-1772.(SCI)

(25) Liu, X.; Shijin Yin.; Chen, S.; Ma, Q., Loureirin B: An Effective Component in Dragon's Blood Modulating Sodium Currents in TG Neurons. Conf Proc IEEE Eng Med Biol Soc, 2005, 5, 4962-4965.(EI)

(26) Xiangming, L.; Su, C.; Shijin Yin.; Zhinan, M., Effects of dragon's blood resin and its component loureirin B on tetrodotoxin-sensitive voltage-gated sodium currents in rat dorsal root ganglion neurons. Sci China C Life Sci, 2004, 47, 340-348.(SCI)


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