冯涛

发布时间:2020-10-21 浏览次数:


                                

 

冯涛    (教授/博士)            

出生年月 1981.05  

民族:汉  

学科专业:药物化学  

研究方向:天然药物化学/真菌化学

电子邮箱:tfeng@mail.scuec.edu.cn

 

教育和工作简历:

1.2020/1-至今,中南民族大学,药学院,教授,硕士生导师

2. 2019/7-2020/6德国莱布尼兹汉诺威大学,访问学者

3. 2015/7-2019/12,中南民族大学,药学院,副教授,硕士生导师

4. 2013/1-2015/6,中国科学院昆明植物研究所,植物化学与西部植物资源持续利用国家重点实验室,副研究员

5. 2010/7-2012/12,中国科学院昆明植物研究所,植物化学与西部植物资源持续利用国家重点实验室,助理研究员

6. 2005/9–2010/6,中国科学院昆明植物研究所硕博连读,药物化学,博士

7. 2000/9–2004/7,西南大学,学士

研究方向:

1. 传统药用植物化学成分的结构与功能

2. 真菌天然产物的结构与功能,及其生物合成

主要荣誉、获奖和社会兼职:

中南民族大学第七届三育人标兵;国家民委中青年英才培养计划;中国科学院卢嘉锡青年人才奖中国科学院院长优秀奖;中国科学院青年创新促进会会员;分获云南省自然科学奖励一、二等奖;国际期刊Natural Products and Bioprospecting编委;Journal of Fungi客座编辑;中国菌物学会菌物化学专业委员会副主任;湖北省药学会药化专委会委员

学术研究:

从事传统药用植物和药用真菌天然产物及其生物功能研究。聚焦真菌特有天然产物结构及其功能,尤其是真菌特有萜类分子,发现具有独特结构的抗炎活性分子“口蘑三萜”,发现具有镇痛活性的真菌特有二萜等。获得新的天然产物700余个,多个分子被评为研究热点。主持国家自然科学基金、省部级项目等科研基金13项,Org LettJ Org Chem, J Nat ProdJ Agri Food Chem等多种学术期刊以第一作者或通讯作者发表研究论文100;获授权专利2项。

1主要科研基金:

1. 国家自然科学基金项目口蘑三萜的挖掘及其抗炎作用研究8187276257万元,主持

2. 国家自然科学基金项目四种有毒高等真菌毒性成分挖掘及毒性评价(81102346)。,22万,主持

3. 中央高校基本科研业务费专项资金重点培育项目:口蘑属三萜分子抗炎先导化合物的发现,40万元,主持。

4. 中国科学院青年创新促进会基金项目:有毒高等真菌毒性分子及其毒性研究,40万元,主持。

5. 横向项目:茜草藤药材化学成分的提取分离、结构鉴定研究及初步活性成分筛选(HZY16029),40万元,主持

6. 横向课题云南中烟工业有限责任公司基于柱层析的红大烟叶中性关键香气馏分剖析及应用(HZY15029),28万元,主持

2)近年部分论著

1. Hong-Lian Ai, Bao-Bao Shi, Wei Li, Juan He, Zheng-Hui Li, Tao Feng*, Ji-Kai Liu*. Bipolarithizole A, an antifungal phenylthiazole-sativene merosesquiterpenoid from the potato endophytic fungus Bipolaris eleusines. Organic Chemistry Frontiers 2022, Doi: 10.1039/D1QO01887F.

2. Bao-bao Shi, Hong-Lian Ai, Kai-Ting Duan, Tao Feng*, Ji-Kai Liu*. Ophiorrhines F and G, key biogenetic intermediates of ophiorrhine alkaloids from Ophiorrhiza japonica and their immunosuppressant activities. Journal of Natural Products 2022, 85, 453-457.

3. Wei-Wei Yu, Jin-Tao Ma, Juan He, Zheng-Hui Li, Ji-Kai Liu, Tao Feng*. Cadinane sesquiterpenoids from the fungus Antrodiella albocinnamomea and their inhibitory activity against nitric oxide production. Phytochemistry 2022, 196, 113081.

4. Fa-Lei Zhang, Tao Feng*. Diterpenes specially produced by fungi: Structures, biological activities and biosynthesis (2010–2020). Journal of Fungi 2022, 8, 244.

5. Yan-Ling Yang, Wei-Wei Yu, Zheng-Hui Li, Ji-Kai Liu, Tao Feng*. Antrodiellins A‒C, triquinane sesquiterpenoids from fungus Antrodiella albocinnamomea with their antibacterial activity. Phytochemistry Letters 2022, 47, 24-27.

6. Qiong Chen, Jun-Jie Yu, Juan He, Tao Feng*, Ji-Kai Liu*. Isobenzofuranones and isocoumarins from kiwi endophytic fungus Paraphaeosphaeria sporulosa and their antibacterial activity against Pseudomonas syringae pv. actinidiae. Phytochemistry 2022, 195, 113050.

7. Quan Dai, Fa-Lei Zhang, Zheng-Hui Li, Juan He*, Tao Feng*. Immunosuppressive sesquiterpenoids from the edible mushroom Craterellus odoratus. Journal of Fungi 2021, 7, 1052.

8. Quan Dai, Fa‐Lei Zhang, Tao Feng*. Sesquiterpenoids specially produced by fungi: structures, biological activities, chemical and biosynthesis (2015–2020). Journal of Fungi 2021, 7, 1026.

9. Hui-Xiang Yang, Jin-Tao Ma, Juan He, Zheng-Hui Li, Rong Huang*, Tao Feng*, Ji-Kai Liu*. Pardinumones A−D: antibacterial polyketide−amino acid derivatives from the mushroom Tricholoma pardinum. ACS Omega 2021, 6, 25089−25095.

10. Juan He, Rui Ma, Zheng-Hui Li, Tao Feng*, Ji-Kai Liu*. Taccachatrones A−G, highly oxidized steroids from the rhizomes of Tacca chantrierii and their cytotoxicity assessment. Journal of Natural Products 2021, 84, 2265−2271.

11. Xue-Wen Yi, Juan He, Li-Tang Sun, Ji-Kai Liu, Guo-Kai Wang*, Tao Feng*. 3-Decalinoyltetramic acids from kiwi-associated fungus Zopfiella sp. and their antibacterial activity against Pseudomonas syringae. RSC Advances 2021, 11, 18827–18831.

12. Dou-Dou Liang, Xue-Wen Yi, Han Wu, Zheng-Hui Li, Guo-Kai Wang,* Gui-Guang Cheng* and Tao Feng,* Antrodillin, an immunosuppressive sesquiterpenoid from higher fungus Antrodiella albocinnamomea. RSC Advances 2021, 11, 1124–1127.

13. Fa-Lei Zhang, Juan He, Tao Feng,* and Ji-Kai Liu*, Melodinines Y1–Y4, four monoterpene indole alkaloids from Melodinus henryi. RSC Advances 2021, 11, 23–29.

14. Fa-Lei Zhang, Chen Shi, Li-Tang Sun, Hui-Xiang Yang, Juan He, Zheng-Hui Li, Tao Feng*, Ji-Kai Liu*, Chemical constituents and their biological activities from the mushroom Pyropolyporus fomentarius. Phytochemistry 2021, 183, 112625.

15. Meng Wang, Jiao-Xian Du, Yang Hui-Xiang, Quan Dai, Ya-Pei Liu, Juan He, Yi Wang, Zheng-Hui Li, Tao Feng,* Ji-Kai Liu*. Sesquiterpenoids from cultures of the basidiomycetes Irpex lacteus. Journal of Natural Products 2020, 83, 1524-1531.

16. Ya-Pei Liu, Quan Dai, Wen-Xuan Wang, Juan He, Zheng-Hui Li, Tao Feng,* Ji-Kai Liu, Psathyrins: antibacterial diterpenoids from Psathyrella candolleana. Journal of Natural Products 2020, 83, 1725-1729.

17. Jing Li, Wen-Xuan Wang, Zheng-Hui Li, Juan He, Rong Huang, Yong-Sheng Zheng, Lan-Qing Li, Xian Wang, Tao Feng*, Ji-Kai Liu*. Xylaridines C and D, unusual thiopyranodipyridine alkaloids from the fungus Xylaria longipes. Organic Letters 2019, 21, 6145−6148.

18. Jing Li, Wen-Xuan Wang, He-Ping Chen, Zheng-Hui Li, Juan He, Yong-Sheng Zheng, Huan Sun, Rong Huang, Qing-Xia Yuan, Xian Wang, Tao Feng*, Ji-Kai Liu*. (±)-Xylaridines A and B, highly conjugated alkaloids from the fungus Xylaria longipes. Organic Letters 2019, 21, 1511-1514.

19. Wen-Xuan Wang, Xin-Xiang Lei, Hong-Lian Ai, Xue Bai, Jing Li, Juan He, Zheng-Hui Li, Yong-Sheng Zheng, Tao Feng*, Ji-Kai Liu*. Cytochalasans from the endophytic fungus Xylaria cf. curta with resistance reversal activity against fluconazole-resistant Candida albicans. Organic Letters 2019, 21, 1108−1111.

20. Tao Feng, Xiao-Qing Gan, Yun-Li Zhao, Shuai-Bing Zhang, He-Ping Chen, Juan He, Yong-Sheng Zheng, Huan Sun, Rong Huang, Zheng-Hui Li*, Ji-Kai Liu*. Tricholopardins A and B, anti-inflammatory terpenoids from the fruiting bodies of Tricholoma pardinum. Journal of Natural Products 2019, 82, 4550.

21. Juan He, Man-Si Yang, Wen-Xiang Wang, Zheng-Hui Li, Waill Ahmed Mohamed Elkhateeb, Ting-Chi Wen, Hong-Lian Ai, Tao Feng*. Anti-phytopathogenic sesquiterpenoid-xanthoneadducts from potato endophytic fungus Bipolaris eleusines. RSC Advances 2019, 9, 128–131.

22. Tao Feng, Kai-Ting Duan, Shi-Jun He, Bin Wu, Yong-Sheng Zheng, Hong-Lian Ai, Zheng-Hui Li, Juan He, Jian-Ping Zuo*, Ji-Kai Liu*. Ophiorrhines A and B, two immunosuppressive monoterpenoid indole alkaloids from Ophiorrhiza japonica. Organic Letters 2018, 20, 7926–7928

23. Wei Li, Juan He, Tao Feng*, Hui-Xiang Yang, Hong-Lian Ai, Zheng-Hui Li, Ji-Kai Liu*. Antroalbocin A, an antibacterial sesquiterpenoid from higher fungus Antrodiella albocinnamomea, Organic Letters 2018, 20(24), 8019–8021

24. Hui-Xiang Yang, Hong-Lian Ai, Tao Feng*, Wen-Xuan Wang, Bin Wu, Yong-Sheng Zheng, Huan Sun, Juan He, Zheng-Hui Li, Ji-Kai Liu*. Trichothecrotocins A–C, antiphytopathogenic agents from potato endophytic fungus Trichothecium crotocinigenum. Organic Letters 2018, 20, 8069–8072

25. Shuai-Bing Zhang, Zheng-Hui Li, Marc Stadler, He-Ping Chen, Ying Huang, Xiao-Qing Gan, Tao Feng*, Ji-Kai Liu*. Lanostane triterpenoids from Tricholoma pardinum with NO production inhibitory and cytotoxic activities. Phytochemistry 2018, 152, 105-112.

26. Shuai-bing Zhang, Ying Huang, Shi-jun He, He-ping Chen, Bin Wu, Shan-yong Li, Zhen-zhu Zhao, Zheng-hui Li, Xian Wang, Jian-ping Zuo, Tao Feng*, Ji-Kai Liu*. Heterocyclic compounds from the mushroom Albatrellus confluens and their inhibitions against lipopolysaccharides-induced B lymphocyte cell proliferation. Journal of Organic Chemistry 2018, 83, 10158−10165.

27. Shuai-Bing Zhang, Ying Huang, Shi-Jun He, He-Ping Chen, Zheng-Hui Li, Bin Wu, Jian-Ping Zuo, Tao Feng*, Ji-Kai Liu*. Albatredines A and B, a pair of epimers with unusualnatural heterocyclic skeletons from edible mushroom Albatrellus confluens, RSC Advances 2018, 8, 23914–23918.

28. Tao Feng, Xue-Mei Li, Jun He, Hong-Lian Ai, He-Ping Chen, Xiao-Nian Li, Zheng-Hui Li, and Ji-Kai Liu, Nicotabin A, a sesquiterpenoid derivative from Nicotiana tabacum. Organic Letters 2017, 19, 5201−5203.

29. Zhen-Zhu Zhao, He-Ping Chen, Bin Wu, Ling Zhang, Zheng-Hui Li, Tao Feng*, Ji-Kai Liu*. Matsutakone and matsutoic acid, two (nor)steroids with unusual skeletons from the edible mushroom Tricholoma matsutake. Journal of Organic Chemistry 2017, 82(15), 7974−7979.

30. Ying Huang, Shuai-Bing Zhang, He-Ping Chen, Zhen-Zhu Zhao, Zhong-Yu Zhou, Zheng-Hui Li, Tao Feng*, Ji-Kai Liu*. New acetylenic acids and derivatives from the edible mushroom Craterellus lutescens (Cantharellaceae). Journal of Agricultural and Food Chemistry 2017, 65, 3835−3841.

3)近年授权专利

1. 冯涛; 刘吉开; 李正辉; 口蘑菌素甲及其制备方法与应用、口蘑菌素乙及其制备方法与应用, 2019-1 1-05, 中国, ZL201810010131.6

2. 冯涛; 刘吉开; 何隽; 李正辉; 石晨 ; 口蘑三萜化合物、其制备方法、提取物及其应用, 2021-12, 中国, ZL202010980531.7



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