郑永胜

发布时间:2019-12-29 浏览次数:


 

 

个人信息

出生年月:1982.4

职称:副教授

研究方向:不对称有机合成方法学、药物化学、天然产物结构修饰

电子邮箱:zhysh3811@163.com  ORCID:0000-0002-1019-5521

学习工作简历

2022/03-至今:中南民族大学药学院  副教授、硕士生导师

2016/08-2022/03:中南民族大学药学院  讲师、硕士生导师

2013/08-2015/07:美国中佛罗里大学化学系  博士后

2010/09-2013/07:中国科学院大学成都有机化学研究所  有机化学  博士

2007/09-2010/07:四川大学华西药学院  药物化学  硕士

2002/09-2006/07:西华大学  制药工程  本科

主讲课程

药物化学、药物合成、药物化学实验

科研项目

1. 国家自然科学基金面上项目,81973208,蛇根草来源的新型选择性B淋巴细胞免疫抑制剂的构效关系和作用机制研究,2020/01-2023/1255万,在研,主持

2. 湖北省自然科学基金面上项目,BZY18013Triazinanes反电子需求环加成反应在类药四氢喹唑啉高效合成及其抗肿瘤活性研究中的应用,2019/01-2020/125万,结题,主持

3.中央高校基本科研业务费专项资金项目,CZQ20011, Triazinanes的直接活化不对称[4+2]环加成反应合成哌啶酮的研究,2020/1-2021/12, 4万,结题,主持

4. 中央高校基本科研业务费专项资金项目,CZQ17010,失B环天然产物Harringtonolide的骨架及类似物高效合成及抗肿瘤、抗感染活性研究,2017/01-2018/12, 2.4万,结题,主持

5. 国家自然科学基金面上项目,21172217β-氨基酸衍生物的不对称合成及其在β-多肽合成中的应用,2012/01-2015/1260万元,已结题,参与

研究论文:

Liang Tu, Limei Gao, Qiang Wang, Zhixing Cao, Rong Huang, Yongsheng Zheng,* and Jikai Liu*, Substrate-Switched Chemodivergent Pyrazole and Pyrazoline Synthesis: [3+2] Cycloaddition/Ring-Opening Rearrangement Reaction of Azadienes with Nitrile Imines. J. Org. Chem. 2022, 87, 3389−3401. if 4.354

Limei Gao, Ruijie Shi, Yuting Tian, Xi Luo, Yongsheng Zheng, and Qiang Wang. Synthesis of Pyrazoles through [3+2] Cyclization of Nitrile Imines with Cinnamaldehydes Followed by Air Oxidation. ChemistrySelect 2021, 6, 1283812842.if 2.109

Ruijie Shi, Limei Gao, Weiji Chen, Yangqing Shi, Zhixing Cao, Yongsheng Zheng,* and Jikai Liu*. Formal [2+2+2] Cycloaddition Reaction of 1,3,5-Triazinanes with diethyl acetylene dicarboxylate: Approach to Tetrahydropyrimidines. Eur. J. Org. Chem. 2021, 44, 5941–5945. if 3.021

Liang Tu, Limei Gao, Xiaomeng Wang, Ruijie Shi, Rupei Ma, Junfei Li, Xiaoshuang Lan, Yongsheng Zheng,* and Jikai Liu,* [3+2] Cycloaddition of Nitrile Imines with Enamides: An Approach to Functionalized Pyrazolines and Pyrazoles. J. Org. Chem. 2021, 86(1), 559−573. if 4.354

Na Li, Liang Tu, Guiguang Cheng, Houling Sa, Zhenghui Li, Tao Feng, Yongsheng Zheng,* Jikai Liu.* Diastereoselective [3+3] cycloaddition reaction of 2-arylideneindan-1,3-diones with b-naphthols: Efficient assemble of immunosuppressive pentacyclic chromanes. Tetrahedron Letters. 2020, 61(10), 151579-151587.(if 2.275)

Y. S. Zheng, L. Tu, N. Li, R. Huang, T. Feng, H. Sun, Z. H. Li, J. K. Liu, Inverse-Electron-Demand [4+2]-Cycloaddition of 1,3,5-triazinanes: Facile Approaches to Tetrahydroquinazolines. Advanced. Synthesis & Catalyst. 2019, 361(1), 44-48. if 5.451

L. Tu, Z. H. Li, T. Feng, S. Y. Yu, R. Huang, J. Li, W. X. Wang, Y. S. Zheng,* J. K. Liu,* Access to Imidazolidines via 1,3-Dipolar Cycloadditions of 1,3,5-Triazinanes with Aziridine. The Journal of Organic Chemistry. 2019, 84(17), 11161-11169. if 4.745

Y. S. Zheng, L. Tu, L. M. Gao, R. Huang, T. Feng, H. Sun, W. X. Wang, Z. H. Li, J. K. Liu. Accessing benzooxadiazepines via formal [4+3] cycloadditions of aza-o-quinone methides with nitrones. Organic & Biomolecular Chemistry, 2018, 16(15), 2639-2642. (if 3.423)

Z.Y. Chu, N. Li, D. Liang, Z. H. Li, Y.S. Zheng,* J. K. Liu. Accessing Substituted Pyrrolidines via Formal [3+2] Cycloaddition of 1,3,5-Triazinanes and Donor-acceptor Cyclopropanes. Tetrahedron Letters. 2018, 59(8), 715-718. (if 2.125)

Y. S. Zheng, J. Cleaveland, D, Richardson. Y. Yuan. “An Oganocatalysis Based Carbocyclic Spiroindoline Synthesis Enables Facile SAR Study at C-2 Position”. Organic. Letters. 2015, 17(17), 4240–4243. if 6.364

Yongsheng Zheng, Ebrahim H. Ghazvini Zadeh, Yu Yuan.  One-Pot, Enantioselective Synthesis of 2,3-Dihydroazulen-6(1H)-one: A Concise Access to the Core Structure of Cephalotaxus Norditerpenes. European Journal of Organic Chemistry. 2016, 2016(12), 2115–2119.if 3.068

Yongsheng Zheng, Muqiong Liu, Yu Yuan. A very mild and selective method for O-benzoylation of hydroxamic acids. Tetrahedron Letters. 2014. 55 (31). 4404-4406. if 2.391

Y. S. Zheng, Z. Y. Xue, L. X. Liu, C. Shu, W. C. Yuan, X. M. Zhang. Highly enantioselective hydrosilylation of N-(1,2-diphenylethylidene)arylamines. Organic & Biomolecular Chemistry. 2013, 11(3), 412-415.if 3.562

本科生指导情况:

2018年 涂亮 校级优秀毕业论文(指导教师)

2020年 李娜 校级优秀毕业论文(指导教师)

2018年 李娜 国家级大学生创新训练项目(指导教师)

2021年 撒厚灵 国家级大学生创新训练项目(指导教师)

Na Li,(李娜,2016级本科生,第一作者 Liang Tu, Guiguang Cheng, Houling Sa, Zhenghui Li, Tao Feng, Yongsheng Zheng,* Jikai Liu.* Diastereoselective [3+3] cycloaddition reaction of 2-arylideneindan-1,3-diones with b-naphthols: Efficient assemble of immunosuppressive pentacyclic chromanes. Tetrahedron Letters. 2020, 61(10), 151579-151587.


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