陈贺平

发布时间:2019-03-11 浏览次数:


出生年月:1990-01

民族:汉

职称:讲师

学科专业:真菌天然产物化学与合成生物学

邮箱:chenhp@mail.scuec.edu.cn


教育经历

2014.09-2017.07:中国科学院昆明植物研究所,药物化学,理学博士

2011.09-2014.07:中国科学院昆明植物研究所,药物化学,理学硕士

2007.09-2011.07:安徽医科大学,中药学,理学学士


工作经历

2017.07至今:中南民族大学药学院(硕士研究生导师)

2019.11-2021.11:日本东京大学研究生院药学系JSPS博士后,合作导师:Ikuro Abe教授


学术兼职情况

Journal of Ginseng Research, Phytochemistry, Phytochemistry Letters, Natural Product and Bioprospecting, Journal of Asian Natural Product Research, Natural Product Research等期刊审稿人Natural Products and Bioprospecting青年编委


个人主页:

ORCID: https://orcid.org/0000-0003-0416-9535

Researchgate: https://www.researchgate.net/profile/He_Ping_Chen2


主持的科研项目:

1. 国家自然科学基金青年基金项目,819035122020.01-2022.12

2. 湖北省自然科学基金青年基金项目,2019CFB3792010.0-2021.9

3. 中国科学院昆明植物研究所植物化学与西部植物资源持续利用国家重点实验室开放基金项目,P2017-KF012018-2020

4. 北京大学天然药物及仿生药物国家重点实验室开放基金项目,K201802062018.12-2019.6

5. 中央高校基本科研业务费专项资金项目平台专项CPT220332022.4-2024.4


5年代表性研究成果:

2022

[1]. Takahiro Mori#*, Yu Nakashima#, Heping Chen#, Shotaro Hoshino, Takaaki Mitsuhashi, Ikuro Abe*. Structure-based redesign of Fe(II)/2-oxoglutarate-dependent oxygenase AndA to catalyze spiro-ring formation. Chem. Commun., 2022, ASAP.

[2]. Hui Tao#, Takahiro Mori#*, Heping Chen, Shuang Lyu, Akihito Nonoyama, Shoukou Lee, Ikuro Abe*. Molecular Insights into the unusually promiscuous and catalytically versatile Fe(II)/-ketoglutarate-dependent oxygenase SptF. Nat. Commun., 2022, 13, 95.

[3]. Shui-Lin Liu#, Lin Zhou#, He-Ping Chen*, Ji-Kai Liu*. Sesquiterpenes with diverse skeletons from histone deacetylase inhibitor modified cultures of the basidiomycete Cyathus stercoreus (Schwein.) De Toni HFG134. Phytochemistry, 2022, 195, 113048.

2021

[4]. Qing-Yuan Wang, He-Ping Chen*, Ji-Kai Liu*. Isopimarane Diterpenes from the Rice Fermentation of the Fungicolous Fungus Xylaria longipes HFG1018. Phytochem. Lett., 2021, 45, 100–104.

[5]. He-Ping Chen, Ikuro Abe*. Microbial Soluble Aromatic Prenyltransferases for Engineered Biosynthesis. Synth. Syst. Biotechnol., 2021, 6, 51–62.

[6]. Zhen-Zhu Zhao, Qi-Lu Zhao, Wei-Sheng Feng, Hai-Rong He, Meng Li, Gui-Min Xue, He-Ping Chen*, Ji-Kai Liu*. Absolute stereostructure assignments of ochracines F–L, chamigrane and cadinane sesquiterpenes from the basidiomycete Steccherinum ochraceum HFG119. RSC Adv., 2021, 11, 18693.

2020

[7]. He-Ping Chen, Zhen-Zhu Zhao, Gui-Guang Cheng, Kuan Zhao, Kai-Yue Han, Lin Zhou, Tao Feng, Zheng-Hui Li, Ji-Kai Liu*. Immunosuppressive nor-isopimarane diterpenes from cultures of the fungicolous fungus Xylaria longipes HFG1018. J. Nat. Prod. 2020, 83, 401–412.

[8]. He-Ping Chen, Jing Li, Zhen-Zhu Zhao, Xinyang Li, Shui-Lin Liu, Qing-Yuan Wang, Ji-Kai Liu*. Diterpenes with bicyclo[2.2.2]octane moieties from the fungicolous fungus Xylaria longipes HFG1018. Org. Biomol. Chem. 2020, 18, 2410–2415.

[9]. He-Ping Chen, Xu Ji, Zheng-Hui Li, Tao Feng, Ji-Kai Liu*. Irlactane and tremulane sesquiterpenes from the cultures of the medicinal fungus Irpex lacteus HFG1102. Nat. Prod. Bioprospect. 2020, 10, 89–100.

[10]. Zhen-Zhu Zhao, Xu-Bo Liang, Wei-Sheng Feng, Gui-Min Xue, Ying-Ying Si, He-Ping Chen*, Ji-Kai Liu*. Cyclic dipeptides with peroxy groups from the fruiting bodies of the edible mushroom Tricholoma matsutake. Tetrahedron Lett. 2020, 61, 151892.

[11]. Zhen-Zhu Zhao, Ji-Kai Liu, He-Ping Chen*. Microporotriol, a new cadinane-type sesquiterpenoid from the cultures of the wood-decay fungus Microporus affinis HFG829. Nat. Prod. Res. 2020, 34, 2194–2201.

2019

[12]. Yang Tang, Zhen-Zhu Zhao, Kun Hu, Tao Feng, Zheng-Hui Li, He-Ping Chen*, Ji-Kai Liu*. Irpexolidal represents a class of triterpenoid from the fruiting bodies of the medicinal fungus Irpex lacteus. J. Org. Chem. 2019, 84, 1845–1852.

[13]. Yang Tang, Zhen-Zhu Zhao, Tao Feng, Zheng-Hui Li, He-Ping Chen*, Ji-Kai Liu*. Triterpenes with unusual modifications from the fruiting bodies of the medicinal fungus Irpex lacteus. Phytochemistry 2019, 162, 21–28.

[14]. Zhen-Zhu Zhao, Kai-Yue Han, Zheng-Hui Li, Tao Feng, He-Ping Chen*, Ji-Kai Liu*. Cytotoxic ergosteroids from the fungus Stereum hirsutum. Phytochemistry Lett. 2019, 30, 143–149.

[15]. Zhen-Zhu Zhao, Xu-Bo Liang, Wei-Sheng Feng, Ya Wu, Yan-Le Zhi, Gui-Min Xue, He-Ping Chen*, Ji-Kai Liu*. Unusual constituents from the medicinal mushroom Ganoderma lingzhi. RSC Adv. 2019, 9, 36931–36939.

[16]. Zhen-Zhu Zhao, Wei-Sheng Feng, Xu-Bo Liang, Gui-Min Xue, Ying-Ying Si, He-Ping Chen*, Ji-Kai Liu*. Ochracines A-E, chamigrane-related norsesquiterpene derivatives from the basidiomycete Steccherinum ochraceum HFG119. Fitoterapia 2019, 139, 104362.

[17]. Kai-Yue Han, Xing Wu, Chenglin Jiang, Rong Huang, Zheng-Hui Li, Tao Feng, He-Ping Chen*, Ji-Kai Liu*. Three new compounds from the actinomycete Actinocorallia aurantiaca. Nat. Prod. Bioprospect. 2019, 9, 351–354.

[18]. Sheng-Xiang Yang, Wen-Ting Zhao, Heng-Ye Chen, Lei Zhang, Ting-Kai Liu, He-Ping Chen*, Jian Yang*, Xiao-Long Yang*. Aureonitols A and B, two new c13-polyketides from Chaetomium globosum, an Endophytic Fungus in Salvia miltiorrhiza. Chem. & Biodivers. 2019, 16, e1900364.

2018

[19]. He-Ping Chen, Zhen-Zhu Zhao, Zheng-Hui Li, Ying Huang, Shuai-Bing Zhang, Yang Tang, Jian-Neng Yao, Lin Chen, Masahiko Isaka, Tao Feng*. Ji-Kai Liu*. Antiproliferative and anti-inflammatory lanostane triterpenoids from the Polish edible mushroom Macrolepiota procera. J. Agric. Food Chem. 2018, 66, 3146–3154.

[20]. He-Ping Chen, Meng-Yuan Jiang, Zhen-Zhu Zhao, Tao Feng, Zheng-Hui Li, Ji-Kai Liu*. Vibralactone biogenesis-associated analogues from submerged cultures of the Fungus Boreostereum vibrans. Nat. Prod. Bioprospect. 2018, 8, 37–45.

[21]. He-Ping Chen, Zhen-Zhu Zhao, Zheng-Hui Li, Tao Feng*, Ji-Kai Liu*. Seco-tremulane sesquiterpenoids from the cultures of the medicinal fungus Irpex lacteu HFG1102. Nat. Prod. Bioprospect. 2018, 8, 113–119.

[22]. Yang Tang, Zhen-Zhu Zhao, Jian-Neng Yao, Tao Feng, Zheng-Hui Li, He-Ping Chen*, Ji-Kai Liu*. Irpeksins A–E, 1,10-seco-eburicane-type triterpenoids from the medicinal fungus Irpex lacteus and Their Anti-NO Activity. J. Nat. Prod. 2018, 81, 2163–2168.

[23]. Yang Tang, Zhen-Zhu Zhao, Zheng-Hui Li, Tao Feng, He-Ping Chen*, Ji-Kai Liu*. Irpexoates A–D, four triterpenoids with malonyl modifications from the fruiting bodies of the medicinal fungus Irpex lacteus. Nat. Prod. Bioprospect. 2018, 8, 171–176.

2017

[24]. Zhen-Zhu Zhao#, He-Ping Chen#, Bin Wu, Ling Zhang, Zheng-Hui Li, Tao Feng*, Ji-Kai Liu*. Matsutakone and matsutoic acid, two (nor)steroids with unusual skeletons from the edible mushroom Tricholoma matsutake. J. Org. Chem. 2017, 82, 7974–7979 (Co-first author).

[25]. He-Ping Chen, Ji-Kai Liu*. Secondary Metabolites from Higher Fungi. Progress in the Chemistry of Organic Natural Products. Springer International Publishing AG  2017, Vol. 106, pp.1–201.


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