药学院英文

Qingpei Liu

Release time:2021-01-10 Number of views:

Date of Birth: December19th, 1988

Nationality: Han

Address: 182 Minzu road, Hongshan District, Wuhan, Hubei Province, P.R.China

E-mail: lqp_2019@scuec.edu.cn

Cell phone: +86-13871248127

 

Education and Work Experience

South-Central University for Nationalities, Wuhan, China Lecturer 2019.08 - Pres.

School of Pharmaceutical Sciences

 

University of Arizona, Tucson, Arizona Postdoc. 2018.07 - 2019.08

College of Agriculture and Life Sciences, Advisor: Istvan Molnar

 

University of Arizona, Tucson, Arizona Joint Ph.D. Student 2015.10 - 2017.10

College of Agriculture and Life Sciences, Advisor: Istvan Molnar

Huazhong Agricultural University, Wuhan, China M.E. & D.E. 2010.09 - 2018.06

College of Food Science and Technology, Advisor: Fusheng Chen, Xiaohong Wang

Huazhong Agricultural University, Wuhan, China B.E. 2006.09 - 2010.06

College of Food Science and Technology

 

Research Interests

Ø Investigation on the biosynthesis pathway and mechanism of fungal natural products

Ø Study on the mechanism of fungal polyketide synthases

Grants

Ø Combinatorial biosynthesis of benzenediol lactone and azaphilone polyketide synthase to create new

active molecules (YZZ19007), Overseas Talent Introduction Project of South-Central University for

Nationalities, ¥692,000, 2019.08-2022.08, holding, under study.

Ø Study on the biosynthesis of azaphilone- and naphthone-type yellow pigments in Monascus (31871780),

NSFC general program, ¥590,000, 2019.01-2022.12, participating, under study.

Ø Study on the transcription regulation mechanism of Monascus secondary metabolism mediated by histone

deacetylase (31671835), NSFC general program, ¥620,000, 2017.01-2020.12, participating, under study.

Ø Minimization of Monascus pigment gene cluster based on inverse biosynthesis analysis (31401631),

NSFC general program, 250,000, 2015.01-2017.12, participating, finished.

Ø Cloning, functional analysis and regulatory expression of Monascus pigment gene cluster (31171649),

NSFC general program, 640,000, 2012.01-2015.12, participating, finished.

Publications

Ø Xiaojing Wang#, Chen Wang#, Lixin Duan#, Liwen Zhang, Hang Liu, Ya-ming Xu, Qingpei Liu, Tonglin

Mao, Wei Zhang, Ming Chen, Min Lin, A. A. Leslie Gunatilaka, Yuquan Xu*, Istvan Molnar*. Rational

reprogramming of O-methylation regioselectivity for combinatorial biosynthetic tailoring of benzenediol

lactone scaffolds. Journal of the American Chemical Society, 2019, 141(10), 4355-4364. (IF: 14.357)

Ø Wanping Chen#, Runfa Chen#, Qingpei Liu#, Yi He, Xiaoli Ding, Lijing Kang, Xiaoxiao Guo, Nana Xie,

Youxiang Zhou*, Yuanyuan Lu, Russell J. Cox, Istvan Molnar*, Mu Li, Yanchun Shao, Fusheng Chen*.

Orange, red, yellow: biosynthesis of azaphilone pigments in Monascus fungi. Chemical Science, 2017,

8(7), 4917-4925. (IF:9.556, Co-author)

Ø Qingpei Liu, Li Cai, Yanchun Shao, Youxiang Zhou, Mu Li, Xiaohong Wang, Fusheng Chen*.

Inactivation of the global regulator LaeA Monascus ruber results in a species-dependent response in

sporulation and secondary metabolism. Fungal Biology, 2016, 120(3): 297-305. (IF:2.699)

Ø Jiao Liu#, Youxiang Zhou#, Tao Yi, Mingming Zhao, Nana Xie, Ming Lei, Qingpei Liu, Yanchun Shao,

Fusheng Chen*. Identification and role analysis of an intermediate produced by a polygenic mutant of

Monascus pigments cluster in Monascus ruber M7. Applied Microbiology and Biotechnology, 2016,

100(16): 7037-7049. (IF:3.67)

Ø Qingpei Liu, Nana Xie, Yi He, Li Wang, Yanchun Shao, Hongzhou Zhao, Fusheng Chen*. MpigE, a gene

involved in pigment biosynthesis in Monascus ruber M7. Applied Microbiology and Biotechnology, 2014, 98(1): 285-296. (IF:3.67)

Ø Nana Xie, Qingpei Liu, Fusheng Chen*. Deletion of pigR gene in Monascus ruber leads to loss of

pigment production. Biotechnology Letters, 2013, 35(9): 1425-1432. (IF:1.846)

Ø Yi He, Qingpei Liu, Yanchun Shao*, Fusheng Chen*. ku70 and ku80 null mutants improve the gene

targeting frequency in Monascus ruber M7. Applied Microbiology and Biotechnology, 2013, 97(11):

4965-4976. (IF:3.67)

Honors and Awards

Ø Honor of Excellent Student of Huazhong Agricultural University, top 2 among 27 Ph.D students in the

College of Food Science and Technology, Huazhong Agricultural University. Nov. 2014

Ø Award for Outstanding Cadres of Student Union, in the College of Food Science and Technology,

Huazhong Agricultural University. Nov. 2014

Ø Honor of Excellent Student of Huazhong Agricultural University, top 5 among 26 graduate students in

the College of Food Science and Technology, Huazhong Agricultural University. May 2013

Ø Third Prize in the National Graduate Student English Contest of Huazhong Agricultural University, top

10 among over 300 graduate students in Huazhong Agricultural University. Jun. 2012

Ø Honor of Excellent Student of Huazhong Agricultural University, top 2 among 26 graduate students in

the College of Food Science and Technology, Huazhong Agricultural University. Sep. 2011

Ø Honor of Excellent Student of Huazhong Agricultural University, top 30 among over 130 undergraduate

students in the College of Food Science and Technology, Huazhong Agricultural University. May 2010

Ø Excellent Party Member in the College of Food Science and Technology, Huazhong Agricultural

University. Jan. 2009

Ø Honor of Excellent Student of Huazhong Agricultural University, top 30 among over 130 undergraduate

students in the College of Food Science and Technology, Huazhong Agricultural University. Sep. 2008

Ø Third Prize of Good Grades, top 13 among over 130 undergraduate students in the College of Food

Science and Technology, Huazhong Agricultural University. Jan. 2007

 

Oral Presentations

Ø International academic conference

“Exploration of the tandem acyl carrier protein domain in Monascus pigment polyketide synthase”, in the International Academic Forum on Traditionally Fermented Foods in the World in Wuhan, China, Nov. 5, 2019.

MpigE, a gene involved in pigment biosynthesis in Monascus ruber M-7”, in the Symposium on Hongqu and Fermented Herbal Medicines in Wuhan, China, Jun. 4, 2014.

Ø Lab meeting (2019)

“Investigation on the biosynthetic pathway of the polyketides in Preussia isomera XL1326”, Nov. 21,

2019.

“Bioinformatics analysis of the gene clusters of four PKS-NRPS in Emericella sp. XL029”, Oct. 27, 2019.

“Investigation on the biosynthetic pathway of the meroterpenoids in Emericella sp. XL029”, Sep. 28, 2019.

 

Reference

Morgan Ames, PhD (morganya@sims.berkeley.edu)

Jinying Chen, PhD (jinying@cis.upenn.edu)