Zheng Yongshen, Ph. D. Associate Professor
Research interests: Organic Synthesis and Medicinal Chemistry
E-mail：zhysh3811@163.com ORCID：0000-0002-1019-5521
EDUCATION AND PROFESSIONAL TRAINING
2016/08-present：School of Pharmaceutical Sciences, Lecturer, Associate Professor、Master supervisor
2013/08-2015/07：University of Central Florida
Advisor: Professor Yuan Yu
2010/09-2013/07：Chinese Academy of Science, Chengdu Institute of Organic Chemistry, Ph.D. in Organic Chemistry, Research Advisor: Zhang Xiaomei
2007/09-2010/07：West China School of Pharmacy, Sichuan University, M.A. in Medicinal Chemistry, Research Advisor: Chen Li
2002/09-2006/07：Xihua University B.S. in Pharmaceutical Engineering
Teaching
Medicinal Chemistry、Medicinal Chemistry Experiment
Fund
1. National Natural Science Foundation of China，81973208，2020/01-2023/12，
2. Hubei Provincial Natural Science Foundation of China，BZY18013，2019/01-2020/12
3.The Fundamental Research Funds for the Central Universities，CZQ20011, 2020/1-2021/12
4.The Fundamental Research Funds for the Central Universities，CZQ17010，2017/01-2018/12
Publications：
1. Luoqin Luo, Limei Gao, Dongqing He, Yuting Tian, Jikai Liu,* Yongsheng Zheng*, Cooperative Pd/Chiral Secondary Amine Enabled Diastereo- and Enantioselective [3+2] Cycloannulation: Synthesis of Polysubstituted Cyclopentanes, Org. Lett., 2025, 27, 1847−1852.
2. Hui Guo, Yuqi Tian, Xing Wu, Liang Tu, Jikai Liu*, Yongsheng Zheng*, Rong Huang*, Efficient assembly and anti-tumor evaluation of novel polycyclic [1,2-a]-fused indoles. Bioorganic Chemistry. 2024, 146, 107289.
3. Liang Tu, Sen Li, Li-Mei Gao,* Bo-Wei Tang, Yong-Sheng Zheng,* and Ji-Kai Liu*, Cooperative Rh/Achiral Phosphoric Acid-Enabled [3+3] Cycloannulation of Carbonyl Ylides with Quinone Monoimines: Synthesis of Benzofused Dioxabicyclo[3.2.1]octane Scaffolds. J. Org. Chem. 2024, 89, 9031−9042.
4. Xi Luo, Sen Li, Yuting Tian, Yuqi Tian, Limei Gao, Qiang Wang,* Yongsheng Zheng,* Atroposelective Construction of Naphthylpyrazoles by Chiral Phosphoric Acid Catalyzed Enantioselective Cross-Coupling of Pyrazoles with Naphthoquinone Esters, Eur. J. Org. Chem. 2024, 27 (23), e202400254.
5. Yuting Tian, Ziyang Chen, Kexin Su, Yongsheng Zheng,* and Jikai Liua,*[2+2+1+1] Cycloaddition Reaction of 1,3,5-Triazinanes with Methylene Compounds: Approach to Hexahydropyrimidines. Adv. Synth. Catal. 2023, 365, 3909–3914.
6. Yuting Tian 1,†, Dongqing He 2,†, Limei Gao*, Yu Zou, Xiaoshuang Liu, Qiang Wang, Enxiang Liang* and Yongsheng Zheng*, Regioselective Reaction of 2-Indolylmethanols with Enamides. Molecules, 2023, 28, 3341.
7. Qinglang Wei+, Liang Tu+, Sen Li, Yongsheng Zheng,* and Jikai Liu,*Palladium-Catalyzed [4+2] Cycloaddition of VinylBenzoxazinanones with 1,3-Indanedione: Approach toSpiro-Tetrahydroquinoline Scaffolds. Eur. J. Org. Chem. 2023, 26, e202300499.
8. Liang Tu, Limei Gao, Qiang Wang, Zhixing Cao, Rong Huang, Yongsheng Zheng,* and Jikai Liu*, Substrate-Switched Chemodivergent Pyrazole and Pyrazoline Synthesis: [3+2] Cycloaddition/Ring-Opening Rearrangement Reaction of Azadienes with Nitrile Imines. J. Org. Chem. 2022, 87, 3389−3401.
9. Limei . Gao+, Xiaomeng Wang+, Qinglang Wei, Kexin Su, Renhong Huang, Ju Guo, Yongsheng Zheng,* and Jikai Liu,* [3+3] Cycloadditions of Azomethine Ylides with Nitrile Imines for the Synthesis of 2,3,4,5-Tetrahydro-1,2,4-Triazine-5-Carboxylates, Eur. J. Org. Chem. 2022, e202200768.
10. Limei Gao, Ruijie Shi, Yuting Tian, Xi Luo, Yongsheng Zheng, and Qiang Wang. Synthesis of Pyrazoles through [3+2] Cyclization of Nitrile Imines with Cinnamaldehydes Followed by Air Oxidation. ChemistrySelect 2021, 6, 12838–12842.
11. Ruijie Shi, Limei Gao, Weiji Chen, Yangqing Shi, Zhixing Cao, Yongsheng Zheng,* and Jikai Liu*. Formal [2+2+2] Cycloaddition Reaction of 1,3,5-Triazinanes with diethyl acetylene dicarboxylate: Approach to Tetrahydropyrimidines. Eur. J. Org. Chem. 2021, 44, 5941–5945.
12. Liang Tu, Limei Gao, Xiaomeng Wang, Ruijie Shi, Rupei Ma, Junfei Li, Xiaoshuang Lan, Yongsheng Zheng,* and Jikai Liu,* [3+2] Cycloaddition of Nitrile Imines with Enamides: An Approach to Functionalized Pyrazolines and Pyrazoles. J. Org. Chem. 2021, 86(1), 559−573.
13. Na Li, Liang Tu, Guiguang Cheng, Houling Sa, Zhenghui Li, Tao Feng, Yongsheng Zheng,* Jikai Liu.* Diastereoselective [3+3] cycloaddition reaction of 2-arylideneindan-1,3-diones with b-naphthols: Efficient assemble of immunosuppressive pentacyclic chromanes. Tetrahedron Letters. 2020, 61(10), 151579-151587.(if 2.275)
14. Y. S. Zheng, L. Tu, N. Li, R. Huang, T. Feng, H. Sun, Z. H. Li, J. K. Liu, Inverse-Electron-Demand [4+2]-Cycloaddition of 1,3,5-triazinanes: Facile Approaches to Tetrahydroquinazolines. Advanced. Synthesis & Catalyst. 2019, 361(1), 44-48.
15. L. Tu, Z. H. Li, T. Feng, S. Y. Yu, R. Huang, J. Li, W. X. Wang, Y. S. Zheng,* J. K. Liu,* Access to Imidazolidines via 1,3-Dipolar Cycloadditions of 1,3,5-Triazinanes with Aziridine. The Journal of Organic Chemistry. 2019, 84(17), 11161-11169.
16. Y. S. Zheng, L. Tu, L. M. Gao, R. Huang, T. Feng, H. Sun, W. X. Wang, Z. H. Li, J. K. Liu. Accessing benzooxadiazepines via formal [4+3] cycloadditions of aza-o-quinone methides with nitrones. Organic & Biomolecular Chemistry, 2018, 16(15), 2639-2642.
17. Z.Y. Chu, N. Li, D. Liang, Z. H. Li, Y.S. Zheng,* J. K. Liu. Accessing Substituted Pyrrolidines via Formal [3+2] Cycloaddition of 1,3,5-Triazinanes and Donor-acceptor Cyclopropanes. Tetrahedron Letters. 2018, 59(8), 715-718. (if 2.125)
18. Y. S. Zheng, J. Cleaveland, D, Richardson. Y. Yuan. “An Oganocatalysis Based Carbocyclic Spiroindoline Synthesis Enables Facile SAR Study at C-2 Position”. Organic. Letters. 2015, 17(17), 4240–4243.
19. Yongsheng Zheng, Ebrahim H. Ghazvini Zadeh, Yu Yuan. One-Pot, Enantioselective Synthesis of 2,3-Dihydroazulen-6(1H)-one: A Concise Access to the Core Structure of Cephalotaxus Norditerpenes. European Journal of Organic Chemistry. 2016, 2016(12), 2115–2119.
20. Yongsheng Zheng, Muqiong Liu, Yu Yuan. A very mild and selective method for O-benzoylation of hydroxamic acids. Tetrahedron Letters. 2014. 55 (31). 4404-4406.
21. Y. S. Zheng, Z. Y. Xue, L. X. Liu, C. Shu, W. C. Yuan, X. M. Zhang. Highly enantioselective hydrosilylation of N-(1,2-diphenylethylidene)arylamines. Organic & Biomolecular Chemistry. 2013, 11(3), 412-415.
