Name: Yang Guangzhong
Sex: Male
Date of Birth: Nov. 27, 1968
Educational background: Ph.D.
Title: Professor
ADDRESS: College of Pharmacy, South-Central University for Nationalities; No 182, Minyuan Road, Hongshan District; Wuhan, Hubei, China, 430074
E-mail: yanggz888@126.com
1 EDUCATION:
B.A. 1986.9-1990.6 Department of chemistry, South Central University for
Nationalities
M. S. 1990.7-1993.6 Institute of Organic synthesis, Central China Normal
University
Ph. D. 1998.9-2001.7 Shanghai Institute of Materia Medica, Chinese Academy of Sciences (SIMM, CAS)
2 WORK EXPERIENCE
1993.7-1998.8 Institute of Organic synthesis, Central China Normal University, Lecturer
2001.12-2003.12 Department of Forest Chemistry, Wood Extraction Laboratory,
Forestry and Forest Products Research Institute, Japan, JSPS
Postdoctoral Fellowship
2004.1-2010.12 College of Pharmacy, South Central University for Nationalities,
Associate Professor
2011.1- at present College of Pharmacy, South Central University for Nationalities,
Professor
3 RESEARCH FIELD
My research interests are in search of novel natural products from ethnomedicines, structure modifications and biological activities of active natural products. Chemical constituents and biological activities of more than 30 ethnomedicinal plants were studied. More than 1000 compounds were isolated and identified from those plants, involving terpenoids, alkaloids, flavonoids, phenylpropanoids and saponins, of which more than 200 new compounds and 10 compounds with new carbon skeleton were identified from those plants. A National Natural Science Foundation of China, two provincial and one national key laboratory projects have been completed. Three provincial science and technology achievement awards were obtained. More than 200 papers have been published in the domestic and foreign academic journals, of which more than 60 papers have been recorded in SCI.
4 PUBLICATIONS
[1] Chen Y; Ma Z. Y.; Teng H. D.; Gan F.; Xiong H.; Mei Z. N.*; Yang G. Z.* Four intricately caged polycyclic polyprenylated acylphloroglucinols from Garcinia multiflora fruits, Org. Chem. Front., 2019, 6, 3085-3092.
[2] Chen Y; Ma Z. Y.; Teng H. D.; Gan F.; Xiong H.; Mei Z. N.*; Yang G. Z.* Adamantyl and homoadamantyl derivatives from Garcinia multiflora fruits, RSC Adv., 2019, 9, 12291-12299.
[3] Teng H. D.; Ren Y. S.; Ma Z. Y.; Tan X.; Xu J.; Chen Y.*; Yang G. Z.* Homoadamantane polycyclic polyprenylated acylphloroglucinols from the fruits of Garcinia multiflora, Fitoterapia, 2019, 137, 104245-104252.
[4] Xu J.; Wang S.; Feng T. H.; Chen Y.*; Yang G. Z.* Hypoglycemic and hypolipidemic effects
of total saponins from Stauntonia chinensis in diabetic db/db mice, J. Cell. Mol. Med., 2018,
22, 6026-6038.
[5] Li J.; Gao R. X.; Zhao D.; Huang X. J.; Chen Y.*; Gan F.; Liu H.; Yang G. Z.∗ Separation and preparation of xanthochymol and guttiferone E by high performance liquid chromatography and high speed counter-current chromatography combined with silver nitrate coordination reaction，J. Chromatogr. A 2017，1511, 143-148.
[6] Chen Y.; Gan F.; Jin S.; Liu H.; Wu S. J.; Yang W. T.; Yang G. Z.* Adamantyl derivatives and rearranged benzophenones from Garcinia xanthochymus fruits，RSC Adv., 2017, 7 (28), 17289- 17296.
[7] Liu H.; Gan F.; Jin S.; Li J.; Chen Y.*; Yang G. Z*. Acylphloroglucinol and tocotrienol derivatives from the fruits of Garcinia multiflora，RSC Adv., 2017, 7 (47), 29295–29301.
[8] Li Y. F.; Zhao P.; Chen Y.; Fu Y. Z.; Shi K.; Liu L.; Liu H.; Xiong M. R.; Liu Q. H.; Yang G. Z.*; Xiao Y. X.* Depsidone and xanthones from Garcinia xanthochymus with hypoglycemic activity and the mechanism of promoting glucose uptake in L6 myotubes, Bioorg. Med. Chem. 2017, 25 (24), 6605-6613.
[9] Xu J.; Gan S.; Li J.; Wang D. B.; Chen Y.; Hu X.*; Yang G. Z*. Garcinia xanthochymus extract protects PC12 cells from H2O2-induced apoptosis through modulation of PI3K/AKT and NRF2/HO-1 pathways, Chin. J. Nat. Med. 2017, 15 (11), 825-833.
[10] Yang X. Z.; Huang Mi.; Yang J.; Wang J. l.; Zheng S. J.; Ma X. H.; Cai J. Y.; Deng S. H.; Shu G. W.*; Yang G. Z*, Activity of Isoliensinine in Improving the Symptoms of Type 2 Diabetic Mice via Activation of AMP-Activated Kinase and Regulation of PPARγ, J. Agric. Food Chem. 2017, 65 (33): 7168-7178.
[11] Chen Y.; He S. W.; Tang C.; Li J.; Yang G. Z.* Caged polyprenylated xanthones from the resin of Garcinia hanburyi, Fitoterapia 2016, 109, 106-112.
[12] Chen Y.; Wang S.; Tian S. T.; Hu X.; Xu J.; Yang G. Z.*; Wang C. Y.* 12b-hydroxy-des-D-
garcigerin A enhances glucose metabolism in insulin-resistant HepG2 cells via the IRS-1/PI3-K/Akt cell signaling pathway, J. Asian Nat. Prod. Res. 2016, 18 (11), 1091-1100.
[13] Chen Y.; Tang C.; Wu Y.; Mo S. S.; Wang S; Yang G. Z.*; Mei Z. N.* Glycosmisines A and B: isolation of two new carbazole–indole-type dimeric alkaloids from Glycosmis pentaphylla and an evaluation of their antiproliferative activities, Org. Biomol. Chem., 2015, 13, 6773-6781.
[14] Chen Y.; Tian E. L.; Hu X.; Li J.; Yang G. Z.*, Glycopentosides D-F, Three NewPhenolic Glycosides from Glycosmis pentaphylla , Helv. Chim. Acta, 2015, 98 (8), 1160-1166.
[15] Tang C.; Zhu L. H.; Chen Y.; Qin R.; Mei Z. N.; Xu J.*; Yang G. Z.*, Synthesis and biological evaluation of oleanolic acid derivative-chalcone conjugates as -glucosidase inhibitors, RSC Adv. 2014, 4 (21), 10862-10874.
[16] Tang C.; Liang Y. J.; Bai S.; He H. W.; Chen Y.; Yang G. Z.*; Fu L. W.*, Synthesis and anti-proliferative evaluation of novel tetrahydrobenzo[4',5']thieno [3',2':5,6]pyrido[4,3-d]pyrimidine derivatives, RSC Adv. 2014, 4 (55), 29187-29192.
[17] Chen Y.; Yang F.; Wang S.; Wang D. B.; Xu J.; Yang G. Z.*, Triterpenoid saponins from Stauntonia chinensis, Bull. Korean Chem. Soc. 2014, 35 (4), 1212-1214.
[18] Chen Y.; He H. W.; Yang G. Z.*, Lycopodium alkaloids from Lycopodium obscurum L. Helv. Chim. Acta 2014, 97 (4), 519-523.
[19] Zhang Y.; Yi P.; Chen Y.; Mei Z. N.; Hu X.*; Yang G. Z.*, Lycojaponicuminol A-F, Cytotoxic serratene triterpenoids from Lycopodium japonicum, Fitoterapia, 2014, 96, 519-523.
[20] Hu X.; Wang S.; Xu J.; Wang D. B.; Chen Y.; Yang G. Z.*, Triterpenoid saponins from Stauntonia chinensis ameliorate Insulin Resistance via the AMP-Activated Protein Kinase and IR/IRS-1/PI3K/Akt Pathways in Insulin-Resistant HepG2 Cells, Int. J. Mol. Sci. 2014, 15 (6), 10446-10458.
[21] Yang H.; Tian S. T.; Wu R. Y.; Chen Y.; Mei Z. N.; Wang C. Y.*; Yang G. Z.*, Glycoborinine induces apoptosis through mitochondrial pathway in HepG2 cells, J. Asian Nat. Prod. Res. 2014, 16 (10), 991-999.
[22] Ge Y. B.; Li M. S.; Mei Z. N.; Yang G. Z.*, Two new flavonol glycosides from the leaves of Elaeagnus pungens, J. Asian Nat. Prod. Res. 2013, 15 (10), 1073-1079.
[23] Li Y. F., Jiang Y.; Huang J. F., Yang G. Z.*, Four new lignans from Schisandra sphenanthera, J. Asian Nat. Prod. Res. 2013, 15 (9), 934-940.
[24] Fan H.; Zheng T.; Chen Y.; Yang G. Z.*, Chemical constituents with free-radical-scavenging activities from the stem of Fissistigma polyanthum, Phcog Mag 2012, 8 (30) 98-102.
[25] Yang G. Z.; Wu Y.; Chen Y.*, Alkaloids from the stems of Glycosmis pentaphylla, Helv. Chim. Acta 2012, 95 (8), 1449-1454.
[26] Fu M.; Feng H J.; Chen Y.; Wang D. B.; Yang G. Z.*, Antioxidant activity of Garcinia xanthochymus leaf, root and fruit extracts in vitro, Chin. J. Nat. Med. 2012, 10 (2), 129-134.
[27] Tang C.; Zhu L. H.; Li J.; Qin R.; Liu C.; Chen Y.; Yang G. Z.*, Synthesis and structure elucidation of five new conjugates of oleanolic acid derivatives and chalcones using 1D and 2D NMR spectroscopy, Magn. Reson. Chem. 2012, 50, 236-241.
[28] Ai Y.; Liang Y. J.; Liu J. C.; He H.W.; Chen Y.; Tang C.; Yang G. Z.*; Fu L. W.*, Synthesis and in vitro antiproliferative evaluation of pyrimido[5,4-c] quinoline-4-(3H)-one derivatives, Eur. J. Med. Chem. 2012, 47 (1), 206-213.
