B.S., 09/2000-07/2004
School of Pharmacy, Wuhan University, Wuhan, Hubei, P. R. China
Major: Pharmacy
Ph.D., 09/2004-11/2009
Department of Medicinal Chemistry, School of Pharmacy, Shandong University, Jinan, Shandong, P. R. China
Major: Medicinal Chemistry
Lecturer, 01/2010-05/2013
College of Pharmacy, South-Central University for Nationalities
Associate professor, 01/2010-present
College of Pharmacy, South-Central University for Nationalities
Visiting Scholar, 12/2014-12/2015
Department of Chemistry, Georgia State University, Atlanta, Georgia, America
Major: Medicinal Chemistry
Research Interests:
1.CADD
2.Antitumor Drugs
List of Publications:
[1] Q. Wang, Q. Shi, L. Huang, Novel Aminopeptidase N Inhibitors with Improved Antitumor Activities, Lett Drug Des Discov, 13 (2016) 98-106.
[2] L. Zhang, Y. Han, Q. Jiang, C. Wang, X. Chen, X. Li, F. Xu, Y. Jiang, Q. Wang, W. Xu, Trend of histone deacetylase inhibitors in cancer therapy: isoform selectivity or multitargeted strategy, Medicinal research reviews, 35 (2015) 63-84.
[3] X. Song, Z. Zhao, X. Qi, S. Tang, Q. Wang, T. Zhu, Q. Gu, M. Liu, J. Li, Identification of epipolythiodioxopiperazines HDN-1 and chaetocin as novel inhibitor of heat shock protein 90, Oncotarget, 6 (2015) 5263-5274.
[4] L. Shuai, Z. Chen, P. Fei, Q. Wang, T. Yang, Spectroscopic analysis on the interaction of ferulic acid and tetramethylpyrazine with trypsin, Luminescence : the journal of biological and chemical luminescence, 29 (2014) 79-86.
[5] H. Gao, W. Guo, Q. Wang, L. Zhang, M. Zhu, T. Zhu, Q. Gu, W. Wang, D. Li, Aspulvinones from a mangrove rhizosphere soil-derived fungus Aspergillus terreus Gwq-48 with anti-influenza A viral (H1N1) activity, Bioorganic & medicinal chemistry letters, 23 (2013) 1776-1778.
[6] J. Zhang, X. Pan, C. Wang, F. Wang, P. Li, W. Xu, L. He, Pharmacophore modeling, 3D-QSAR studies, and in-silico ADME prediction of pyrrolidine derivatives as neuraminidase inhibitors, Chemical biology & drug design, 79 (2012) 353-359.
[7] Q. Li, H. Fang, X. Wang, G. Hu, Q. Wang, W. Xu, Novel potent 2,5-pyrrolidinedione peptidomimetics as aminopeptidase N inhibitors. Design, synthesis and activity evaluation, Bioorganic & medicinal chemistry letters, 22 (2012) 850-853.
[8] L. Zhang, H. Zhu, Q. Wang, H. Fang, W. Xu, M. Li, Homology modeling, molecular dynamic simulation and docking studies of cyclin dependent kinase 1, Journal of molecular modeling, 17 (2011) 219-226.
[9] J. Su, Q. Wang, J. Feng, C. Zhang, D. Zhu, T. Wei, W. Xu, L. Gu, Engineered Thermoplasma acidophilum factor F3 mimics human aminopeptidase N (APN) as a target for anticancer drug development, Bioorganic & medicinal chemistry, 19 (2011) 2991-2996.
[10] Y. Luan, Q. Wang, N. Liu, J. Mou, X. Jiao, H. Fang, M. Li, W. Xu, Synthesis and activity evaluation of a new bestatin derivative LYP2 as an aminopeptidase N inhibitor, Anti-cancer drugs, 22 (2011) 99-103.
[11] J. Mou, H. Fang, Y. Liu, L. Shang, Q. Wang, L. Zhang, W. Xu, Design, synthesis and primary activity assay of bi- or tri-peptide analogues with the scaffold l-arginine as amino-peptidase N/CD13 inhibitors, Bioorganic & medicinal chemistry, 18 (2010) 887-895.
[12] K. Yang, Q. Wang, L. Su, H. Fang, X. Wang, J. Gong, B. Wang, W. Xu, Design and synthesis of novel chloramphenicol amine derivatives as potent aminopeptidase N (APN/CD13) inhibitors, Bioorganic & medicinal chemistry, 17 (2009) 3810-3817.
[13] L. Shang, H. Fang, H. Zhu, X. Wang, Q. Wang, J. Mu, B. Wang, S. Kishioka, W. Xu, Design, synthesis and SAR studies of tripeptide analogs with the scaffold 3-phenylpropane-1,2-diamine as aminopeptidase N/CD13 inhibitors, Bioorganic & medicinal chemistry, 17 (2009) 2775-2784.
[14] J. Mou, H. Fang, F. Jing, Q. Wang, Y. Liu, H. Zhu, L. Shang, X. Wang, W. Xu, Design, synthesis and primary activity evaluation of L-arginine derivatives as amino-peptidase N/CD13 inhibitors, Bioorganic & medicinal chemistry, 17 (2009) 4666-4673.
[15] Y. Liu, L. Shang, H. Fang, H. Zhu, J. Mu, Q. Wang, X. Wang, Y. Yuan, W. Xu, Design, synthesis, and preliminary studies of the activity of novel derivatives of N-cinnamoyl-L-aspartic acid as inhibitors of aminopeptidase N/CD13, Bioorganic & medicinal chemistry, 17 (2009) 7398-7404.
[16] X. Li, Y. Wang, J. Wu, Y. Li, Q. Wang, W. Xu, Novel aminopeptidase N inhibitors derived from antineoplaston AS2-5 (Part II), Bioorganic & medicinal chemistry, 17 (2009) 3061-3071.
[17] J. Zhang, Q. Wang, H. Fang, W. Xu, A. Liu, G. Du, Design, synthesis, inhibitory activity, and SAR studies of hydrophobic p-aminosalicylic acid derivatives as neuraminidase inhibitors, Bioorganic & medicinal chemistry, 16 (2008) 3839-3847.
[18] Q. Wang, M. Chen, H. Zhu, J. Zhang, H. Fang, B. Wang, W. Xu, Design, synthesis, and QSAR studies of novel lysine derives as amino-peptidase N/CD13 inhibitors, Bioorganic & medicinal chemistry, 16 (2008) 5473-5481.
[19] L. Shang, Q. Wang, H. Fang, J. Mu, X. Wang, Y. Yuan, B. Wang, W. Xu, Novel 3-phenylpropane-1,2-diamine derivates as inhibitors of aminopeptidase N (APN), Bioorganic & medicinal chemistry, 16 (2008) 9984-9990.
[20] J. Zhang, Q. Wang, H. Fang, W. Xu, A. Liu, G. Du, Design, synthesis, inhibitory activity, and SAR studies of pyrrolidine derivatives as neuraminidase inhibitors, Bioorganic & medicinal chemistry, 15 (2007) 2749-2758.
[21] L. Zhang, J. Zhang, H. Fang, Q. Wang, W. Xu, Design, synthesis and preliminary evaluation of new cinnamoyl pyrrolidine derivatives as potent gelatinase inhibitors, Bioorganic & medicinal chemistry, 14 (2006) 8286-8294.
