Pro. Xian-Ju Huang
Personal InformationDate of birth 18-09-1972
Place of Birth Xiantao (Hubei Province)
University of Tennessee at Knoxville,
Knoxville, TN, USA
Date of Completion: Sep, 2013 – Sep, 2014
Area of Study: Molecular Biology
Thesis: Molecular mechanism for anti-diabetes effect of ethnodrug.
Postdoctor of Veterinary Pharmacology
Huazhong Agriculture University,
Wuhan, Hubei, China
Date of Completion: June, 2010
Area of Study: Veterinary Pharmacology
Thesis: ROS Mediated Adrenal Toxicity and Aldosterone Release Induced by quinoxaline 1, 4 –di-N-oxide derivatives (QdNOs)
Doctor of Pharmacology
Tongji medical college, Huazhong University of Science,
Wuhan, Hubei, China
Date of Graduation: June/July, 2008
Area of Study: Neuropharmacology
Thesis: Neuroprotective Effect of Cactus Polysaccharides on Rat Cerebral Ischemia in Vitro and in Vivo
Master of Pharmacology
Medical college of Wuhan University
Wuhan, Hubei, China
Date of Graduation: December, 2001
Area of Study: Cardiac Pharmacology
Thesis: The Pharmaceutical Studies of Liensinine
Bachelor of Science
China Pharmaceutical University
Nanjing, Jiangsu, China
Date of Graduation: June, 1995
Area of Study: Pharmacology of TCM
Expertise in drug exploration as well as research of pharmacological effect and mechanism of natural products.
Toxicology, Pharmacology, Acute and subchronic studies, Plant extraction, Ethnopharmacology, Natural Products
ØWorking as Professor in South-Central University for Nationalities, Wuhan, China (From December, 2011 to till now).
ØWorking as associate professor in Yangtze University, Jinzhou, China. (From June, 2005 to June, 2008).
ØOne year work experience as Lab Incharge in University of Tennessee at Knoxville, USA (From September, 2013 to September, 2014).
Awards & Honors:
ØRecipient of First grade prize in Hubei Sociaty of Toxicology. ROS mediated cytotoxicity of porcine adrenocortical cells induced by QdNOs derivatives in vitro. Wuhan City, 2010.04.
Øoutstanding thesis in Chinese Sociaty of Toxicology. Mechanism of adrenal toxicity induced by long term feed of mequindox. GuiYang City, 2009.08.
ØThird prize of technology improvement in Hubei province. (Investigation and application for adsorption of minipump apparatus infusionis on cardiovascular drugs. 2008.12.
ØSecond grade prize of outstanding thesis in Wuhan City. Interactions of NADPH oxidase, renin-angiotensin-aldosterone system and reactive oxygen species in mequindox-mediated aldosterone secretion in Wistar rats. Wuhan City 2012.03
Membership of Professional Bodies
ØMember of American Society of Toxicology (USA)
ØCouncil member of Hubei Toxicology Society
ØStanding Committee member of Toxicological and Security Research Branch of China Association of Chinese Medicine
ØCouncil member of Prescription Dosage-Potency Research Branch of TCM World Union
ØCouncil member of Prevention Disease Branch of Chinese National Health Industry
ØStanding Committee member ofInferior Health Branch of HubeiAssociation of Chinese Medicine
Articles Published in Referred Journals
Yue-bin Ge, Zhi-gang Wang, Ying Xiong, Xian-ju Huang*, Zhi-nan Mei, Zong-guo Hong. Anti-inflammatory and blood stasis activities of essential oil extracted from Artemisia argyi leaf in animals. Journal of Natural Medicines. 2016, 70(3): 1-8.
Yue-Bin Ge, Yi Jiang, Huan Zhou, Mi Zheng, Jun Li, Xian-Ju Huang*, Yue Gao. Antitoxic effect of Veratrilla baillonii on the acute toxicity in mice induced by Aconitum brachypodum, one of the genus Aconitum. Journal of Ethnopharmacology. 179 (2016) 27–37.
Huang, X.J., Li J., Mei Z.Y., Chen G.X., 2016. Gentiopicroside and sweroside from Veratrilla baillonii Franch induced phosphorylation of Akt and suppressed Pck1 expression in hepatoma cells. Biochemistry & Cell Biology. 94(3): 270-278.
You Yu, Xue-Jia Yi, Zhi-Yi Mei, Jun Li, Xian-Ju Huang*, Guang-Zhong Yang, Li-Qun Ma, Yue Gao. The water extract of Veratrilla baillonii could attenuate the subacute toxicity induced by Aconitum brachypodum. Phytomedicine. 2016, 23: 1591-1598.
Xian-Ju Huang*. Antitoxic effect of baicalin and glycyrrhetic acid on PC12 cells induced by aconitum brachypodum diel. African journal of pharmacy and pharmacology. 2015, 424-432.
Zhou Lan, Chao Hu, Yamin Huang, Lvyi Chen, Chao Ma, Zhinan Mei, Qinxiong Lin, Xianju Huang, Xukun Deng. Safety assessment of saponins extract in Dolichos falcatus Klein: Subchronic study in Sprague-Dawley rats. Journal of ethnopharmacology. 2015, 174:424-432.
Chao Hu, Qiande Liang, Xianglin Tang, Yuguang Wang, Zengchun Ma, Chengrong Xiao, Hongling Tan, Yue Gao, Xianju Huang*. In vivo metabolite identification of bakuchiol in rats by UPLC/ESI–PDA–QTOF–MS. Fitoterapia 106 (2015) 129–134.
Memory of toxic ethnodrug in China. Beijing: Science publishing house.
Ren Wei, Zhou Huan, Xian-Ju Huang* and Gao Yue. Anti-Inflammatory Effects of Bullatine A on LPS-Induced RAW264.7 Cells by Endoplasmic Reticulum Stress. Interdisciplinary Journal of Microinflammation. 2014,1(2):1-5.
Jun Li, Wei Ren, Xian-Ju Huang*, Da-Jiang Zou, Xin Hu. Bullatine A, a diterpenoid alkaloid of the genus Aconitum, could attenuate ATP-induced BV-2 microglia death/apoptosis via P2X receptor pathways. Brain Research Bulletin. 2013， 97：81– 85.
Xian-Ju Huang, Wei Ren, Jun Li, Lv-Yi Chen, Zhi-Nan Mei. Anti-inflammatory and Anticancer Activities of Ethanol Extract of Pendulous Monkshood Root in vitro. Asian Pacific Journal of Cancer Prevention, 2013，14（6）：3569-3573.
Li-Si Wei, Su Chen, Xian-Ju Huang, Jing Yao, Xiang-Ming Liu. Material basis for inhibition of dragon’s blood on capsaicin-induced TRPV1 receptor currents in rat dorsal root ganglion neurons. European Journal of Pharmacology. 2013, 702: 275-284.
Lvyi Chen, Mahmutjian Mola, Xukun Deng, Zhinan Mei, Xianju Huang, Guangwen Shu, Liuhong Wei, Xiaomin Hou, Zhou Lan, Qinxiong Lin. Dolichos falcata Klein attenuated the inflammation induced by monosodium urate crystals in vivo and in vitro. Journal of Ethnopharmacology, 2013, 150(2): 545-552.
Su Chen, Xianju Huang, Xiangming Liu. Reverse Pharmacology and the R&D of Modern Analgesic Based on Traditional Medicines. Traditional Chinese Medicine. 2012, 1, 1-8.
Wei Ren, Lin Yuan, Jun Li, Xian-Ju Huang*, Su Chen, Da-Jiang Zou1, Xiangming Liu, Xin-Zhou Yang. Ethanolic extract of aconiti brachypodi radix attenuates nociceptive pain probably via inhibition of voltage-dependent Na+ channel. Afr J Tradit Complement Altern Med. 2012, 9(4):574-583.
Xu Wang, Xian-Ju Huang*（Co-first）, Awais Ihsan, Zhao-Ying Liu, Ling-Li Huang, Hua-Hai Zhang, Hong-Fei Zhang, Wen Zhou, Qin Liu, Xi-Juan Xue, Zong-Hui Yuan.Metabolites and JAK/STAT pathway were involved in the liver and spleen damage in male Wistar rats fed with mequindox. Toxicology. 2011, 280: 126-134.
Da-Jiang Zou, Qiao-Feng Zheng, Xian-Ju Huang, Xu Wang, Awais Ihsan. Potential benefits of quinoxaline 1, 4-dioxides in aldosterone dysmetabolism disease. Open Journal of Animal Sciences. 2011, 1 (3): 121-127.
Xian-Ju Huang, Hua-Hai Zhang, Xu Wang, Ling-Li Huang, Ling-Yan Zhang, Cai-Xia Yan, Zong-Hui Yuan. ROS mediated cytotoxicity of porcine adrenocortical cells induced by QdNOs derivatives in vitro. Chemico-Biologicol Interactions. 2010, 185: 227-234. IF: 3.033.
Xian-Ju Huang,Xu Wang, Awais Ihsan, Qin Liu, Xi-Juan Xue, Shi-Jia Su, Chun-Hui Yang, Zong-Hui Yuan. Interactions of NADPH oxidase, renin-angiotensin-aldosterone system and reactive oxigen species in mequindox -mediated aldosterone secretion in wistar. Toxicology Letters. 2010.，198：112-118. IF: 3.249.
Awais Ihsan, Xu Wang, Xian-Ju Huang, Yu Liu; Qin Liu; Wen Zhou, Zong-Hui Yuan. Acute and Subchronic Toxicological Evaluation of Mequindox in Wistar Rats. Regulatory Toxicology and Pharmacology. 2010, 57: 307-314. IF: 2.36.
Xian-Ju Huang, Awais Ihsan, Xu Wang, Meng-Hong Dai, Yu-Lian Wang, Shi-Jia Su, Xi-Juan Xue, Zong-Hui Yuan. Long-term dose-dependent response of Mequindox on aldosterone, corticosterone and five steroidogenic enzyme mRNA in the adrenal of male rats. Toxicology Letters. 2009, 191:167-173. IF: 3.249.
LÜ Qing，Xu Xu-Lin，He Zhi，Huang Xian-Ju，Guo Lian-Jun，Wang Hong-Xing. Guattegaumerine Protects Primary Cultured Cortical Neurons Against Oxidative Stress Injury Induced by Hydrogen Peroxide Concomitant with Serum Deprivation. Cellular and Molecular Neurobiology. 2009, 29(3):355-64. IF: 2.55.
Xianju Huang, Qin Li, Huige Li, Lianjun Guo. Neuroprotective and Antioxidative Effect of Cactus Polysaccharides In Vivo and In Vitro. Cellular and Molecular Neurobiology. 2009(29): 1211-1221. IF: 2.55.
Qin Li*，Huang Xian-Ju*（Co-first），He Wei, Ding Jie, Jia Jun-Ting, Fu Gang, Wang Hong-Xing, Guo Lian-Jun. Neuroprotective Potential of Fasudil Mesylate in Brain Ischemia- Reperfusion Injury of Rats. Cellular and Molecular Neurobiology. 2009, 29: 169-180.IF: 2.55.
21. Xianju Huang, Qin Li, Yingpei Zhang, Qing Lü, Lianjun Guo, Lin Huang, Zhi He. Neuroprotective effects of Cactus Polysaccharide on oxygen and glucose deprivation induced damage in rat brain slices. Cellular and Molecular Neurobiology. 2008, 28:559-568. IF: 2.55.
22. Xianju Huang，Qin Li, Lianjun Guo, Zankai Yan. Protection of cactus polysaccharide against H2O2-induced damage in the rat cerebral cortex and hippocampus: Differences in time of administration. Neuronal Regenenal Research. 2008, 3(1):14-8.
23. Huang Xian-ju, Zhu Hui-ling, Deng Yun-fan, Xiao Kui, Chen Jian-hua. Establishment of Type 2 Diabetes Mellitus Model on Rabbit and study of the Total Flavone of Ampelopsis on Diabetes Rabbit (Abstract). Acta Pharmacologica Sinica. 2006, July: 297. IF: 1.676.
1.The interaction of of Veratrilla baillonii Franch and aconitum medicine and their apparent biological characteristics for toxicity/detoxification. Chinese national Science Foundation（No. 81374064）2014.01~2017.12 [Host]
2.Toxicity - efficiency evaluation and investigation of characteristics concocted technique of JiangBianYiWanShui and other ethnical drug. National Twelfth Five-Year Plan for Science & Technology Support (No. 2012BAI27B00-2) 2012.01 ~ 2014.12 [Host]
3.Investigation of toxicity-effect relationship of Aconitum brachypodum diel based on the target of soldium channal. Chinese national Science Foundation（No. 81102897）2012.01~2014.12 [Host]
4.Oxidative Stress mechanism of adrenal toxicity induced by quinoxalines. China Postdoctoral Science Foundation (No.200902441). 2009.01～2010.06 [Host]
5.Molecular mechanism of aldosterone synthesis and release of adrenal cells of pigs induced by quinoxalines. China Postdoctoral Science Foundation (No.20080440949). 2008.07～2009.07 [Host]
6.Investigation of the mechanism between oxidative stress and quinoxaline toxicity. National Basic Research Program of Huazhong Agriculture University (No.2009QC001). 2010.01～2011.12 [Host]
7.Investigation of Protective effect of cactus polysaccharides on injured brain slices of rats. Youth Project of Department of Education in Hubei province (No.Q200712004). 2007.01～2009.12 [Host]
8.Influence of ampelopsin on NO/NOS in diabetes animals. Health Department in Hubei province (No.JX2C27). 2005.01～2006.12 [Host]
9.Influence of liensinine on contraction of isolated aortic ring. Medical school of Yangze University. 2003.07～2004.07. [Host]