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Structure, Function and Physiological Modeling of Membrane Ion Channels

It mainly implemented research on the structure and function of ion channels and the mechanism of related heart and brain diseases.

To conduct a systematic study of gating characteristics of HCN channel, TTX-R sodium channel, TRPV1 channel, drug action site, specific blockers. It illustrates the occurrence of chronic pain and the mechanism of signal transduction, determines the analgesic mechanism and corresponding medicinal substances of Dai drug Dragon Blood by the study of the sensitization of substance P and other neuroregulatory factors to ion channels in neuron membranes; it finds that the Complexins of secretory regulatory proteins plays a dual role of activation and inhibition in the release of neurotransmitters, and the regions of action were differentiated, and the neuroactive band proteins Piccolo and Bassoon can maintain the aggregation of synaptic vesicles in the synapses, but they are not directly involved in the regulation of neurotransmitter secretion.

Biomedical Signal Detection and Processing

It mainly conducts a research on detection and processing of various signals in human body, and to explore the relationship between physiological and psychological parameters and diseases

It puts forward the induce model of natural reading simulation, realized the ERPs experiments induced brain signals and noise induced brain effective separation, the model was used to construct a novel brain - computer interface, and implements a preliminary online demo system, can use brainwave typing and network dialogue, communication rate reached the international advanced level; proposed to take use of the space-time combination of P2-N2-P3 composite waves from different channels as the communication feature carrier to construct the single localization cognitive signal from continuous EEG signals, which makes the average recognition accuracy more than 95%.

Visual Cognitive Computing and Medical Image Processing

It mainly conducts research on detection and processing of various signals in human body, to explore the relationship between physiological and psychological parameters and diseases.

It establishes the linear structure detection model of the image by simulating the perceptual mechanism of visual cortex; establishes the probability model of contour perception organization by defining a standard of line segment aggregation; comes up with a dynamic information detection and feature extraction method to simulate the mechanism of visual cortex, and discusses a control method - to connect different regions of visual cortex, which provided a computational method for target recognition; it built the deformable models of key points in different scale space,  which can overcome the problem of poor registration accuracy caused by the deformation of tissues and organs in medical images; it proposed a fast moving algorithm and multi-scale space hierarchical segmentation algorithm based on piecewise parabola fitting, which realize the  automatic segmentation of cervical spine bone X-ray and ultrasound images.

Biomedical Sensing and Instrumentation

It mainly conducts the study on quantitative analysis of the components of biological substances based on biosensor.

It realizes the water solubility of carbon nanotubes, prepares NO sensing models on the basis of polyazo cochineal red-carbon nanotube composite membrane, platinum nanoparticle -acetylene black composite membrane and polyalizarin red-carbon nanofiber composite membrane, and successfully detectes the content of NO released by hepatocytes and macrophages of mouse and guinea pig; it designs a kind of reflective displacement sensor by using composite optical fiber bundle, which is successfully applied to the measurement of micro-displacement and high-frequency vibration in narrow space. It also presents a fluorescence fiber sensor based on dual-frequency phase modulation technology realizes the single point multi-parameter measurement of biochemical index (pO2/pH).





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