生命科学学院

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刘庆华简介


作者:    浏览次数:    责任编辑:    审核:    上传:    发布时间:2016-11-18

姓名:刘庆华
职务/职称:教授
通讯地址:中南民族大学生科院8D307
E-mailqinghualiu95@163.com


一、学习及工作简历:

学习

1981.9-1986.6: 华中科技大学同济医学院临床医学儿科专业,获医学学士学位。

1988.9-1991.6: 华中科技大学同济医学院生理学专业,获医学硕士学位。

1995.6-2000.8: 德国科隆, 科隆大学(Cologne University)医学院, 获医学博士学位。

工作

1986.7-1988.9:  山东大学医学院教务处医学教育研究室,助教。

1991.9-1995.6:  华中科技大学同济医学院生理系,讲师。

2000.6-2003.12: 美国费城, 宾夕法尼亚大学动物医学院生物病理系,副研究员。

2004.1-2010.3: 美国纽约洲奥尔巴尼, 奥尔巴尼医学院心血管科学中心,助理教授。

2010.3-至今中南民族大学生命科学学院医学生物研究所,教授、所长。

 

主要社会兼职

湖北省细胞生物学会理事

湖北省生理学会理事

湖北省实验动物学会理事

三、科研活动及成果:

(一)主要研究方向

分子及离子信号的产生及转导机制及在干细胞分化发育,免疫系统,肌肉系统中的生理和病理作用,以及药物研发。

(二)主持或参与的科研项目
 1. 
主持:国家自然科学基金面上项目(31571200), 2016-2019年;
 2.
主持:国家自然科学基金面上项目(30971514), 2010-2012年;

 3. 主持:国家自然科学基金主任基金(31140087), 2012-2012年;

 4. 参与:科技部“973(2011CB809100), 2011-2015

 


(三)科研成果及荣誉

12010年湖北省自然科学二等奖。


(四)代表性论文:(*通讯作者)

1. Zhou Q, Yang X, Xiong M, Xu X, Zhen L, Chen W, Wang Y, Shen J, Zhao P*, Liu QH*. Chloroquine Increases Glucose Uptake via Enhancing GLUT4 Translocation and Fusion with the Plasma Membrane in L6 Cells. Cell Physiol Biochem. 2016;38(5):2030-40. doi: 10.1159/000445562. Epub 2016 May 9. PMID: 27160165

2. Lv Y, Xue L, Cai C, Liu QH, Shen J. Deficiency of myotubularin-related protein 14 influences body weight, metabolism, and inflammation in an age-dependent manner. Cell Biosci. 2015 Dec 21;5:69. doi: 10.1186/s13578-015-0062-6. eCollection 2015. PMID: 26697164

3. Song T, Hao Q, Zheng YM, Liu QH, Wang YX. Inositol 1,4,5-trisphosphate    activates TRPC3 channels to cause extracellular Ca2+ influx in airway smooth muscle cells. Am J Physiol Lung Cell Mol Physiol. 2015 Oct 9:ajplung.00148.2015. doi: 10.1152/ajplung.00148.2015. [Epub ahead of print]

(PMID: 26453517)

4. Tan L, Chen W, Wei MY, Shen J, Yu MF, Yang G, Guo D, Qin G, Ji G, Liu QH*.

Relaxant action of plumula nelumbinis extract on mouse airway smooth muscle.

Evid Based Complement Alternat Med. 2015;2015:523640. doi: 10.1155/2015/523640. Epub 2015 Feb 11. PMID:25763092

 5. Xu JC, Peng YB, Wei MY, Wu YF, Guo D, Qin G, Ji G, Shen J, Liu QH*. Chloroquine Inhibits Ca Signaling in Murine CD4(+) Thymocytes. Cell Physiol Biochem. 2015;36(1):133-40. doi: 10.1159/000374058. Epub 2015 Apr 27.

(PMID: 25925287)

6. Wei MY, Xue L, Tan L, Sai WB, Liu XC, Jiang QJ, Shen J, Peng YB, Zhao P, Yu MF, Chen W, Ma LQ, Zhai K, Zou C, Guo D, Qin G, Zheng YM, Wang YX, Ji G, Liu QH*. Involvement of large-conductance Ca2+-activated K+ channels in chloroquine-induced force alterations in pre-contracted airway smooth muscle.

PLoS One. 2015 Mar 30;10(3):e0121566. doi: 10.1371/journal.pone.0121566. eCollection 2015. PMID: 25822280 Free PMC Article

7. Zhou J, Cheng M, Boriboun C, Ardehali MM, Jiang C, Liu Q, Han S, Goukassian DA, Tang YL, Zhao T, Zhao M, Cai L, Richard S, Kishore R, Qin G. Inhibition of Sam68 triggers adipose tissue browning. J Endocrinol. 2015 May 1. pii: JOE-14-0727. [Epub ahead of print]. (PMID: 25934704)

8. Wu M, Zhou J, Cheng M, Boriboun C, Biyashev D, Wang H, Mackie A, Thorne T, Chou J, Wu Y, Chen Z, Liu Q, Yan H, Yang Y, Jie C, Tang YL, Zhao TC, Taylor RN, Kishore R, Losordo DW, Qin G. E2F1 suppresses cardiac neovascularization by down-regulating VEGF and PlGF expression. Cardiovasc Res. 2014 Dec 1;104(3):412-22. doi: 10.1093/cvr/cvu222. Epub 2014 Oct 23. (PMID: 25341896)

9. Savoia CP, Liu QH, Zheng YM, Yadav VR, Zhang Z, Wu LG, Wang YX Calcineurin upregulates local Ca2+ signaling through ryanodine receptor-1 in airway smooth muscle cells. Am J Physiol Lung Cell Mol Physiol. 2014 Sep 19. pii: ajplung.00149.2014. [Epub ahead of print] PMID: 25239916 [PubMed - as supplied by publisher]. (PMID: 25239916)

10. Ting Zhang, Xiao-Jing Luo, Wen-Bo Sai, Meng-Fei Yu, Wen-Er Li, Yun-Fei Ma, Weiwei Chen, Kui Zhai, Gangjian Qin, DongLin Guo, Yun-Min Zheng, Yong-Xiao Wang, Jin-Hua Shen, Guangju Ji, Qing-Hua Liu*. Non-selective cation channels mediate chloroquine-induced relaxation in precontracted mouse airway smooth muscle. Plos One, 2014 Jul 3;9(7):e101578. doi: 10.1371/journal.pone.0101578. (PMID: 24992312)

11. Guo D, Yu M, Liu QH, Cox RH, Liu T, Yan GX. Ventricular hypertrophy amplifies transmural dispersion of repolarization by preferentially increasing the late sodium current in endocardium. J Electrocardiol. 2014 Apr 13. pii: S0022-0736(14)00127-7. doi: 10.1016/j.jelectrocard.2014.04.004. [Epub ahead of print] PMID: 24813353 [PubMed - as supplied by publisher]. (PMID: 24813353)

12. Liu J, Lv Y, Liu QH, Qu CK, Shen J. Deficiency of MTMR14 promotes autophagy and proliferation of mouse embryonic fibroblasts. Molecular and cellular biochemistry, 2014 Mar 13. [Epub ahead of print]. (PMID: 24623267)

13. Zhai K, Chang Y, Wei B, Liu Q-H, Leblais V, Fischmeister R, Ji G. Phosphodiesterase types 3 and 4 regulate the phasic contraction of neonatal rat bladder smooth myocytes via distinct mechanisms. Cellular Signalling. 26(5):1001-10, 2014 May. (PMID: 24463006)

14. Sai WB, Yu MF, Wei MY, Lu Z, Zheng YM, Wang YX, Qin G, Guo D, Ji G, Shen J, Liu Q-H*. Bitter tastants induce relaxation of rat thoracic aorta precontracted with high K(+). Clinical and Experimental Pharmacology & Physiology. 41(4):301-8, 2014. (PMID:24552423)

15. Ge YB, Dai Q, Wan DR, Liu Q-H*, Mei ZN. Relaxant effect of 1-butanol fraction from Elaeagnus pungens leaf through inhibiting l-type Ca(2+) channel on guinea pig tracheal smooth muscle. J Ethnopharmacol. 150 (1):196-201, 2013. (PMID:23988619)

16. Tuo QR, Ma YF, Chen W, Luo XJ, Shen J, Guo D, Zheng YM, Wang YX, Ji G, Liu Q-H*. Reactive oxygen species induce a Ca(2+)-spark increase in sensitized murine airway smooth muscle cells. Biochem Biophys Res Commun. 434(3):498-502, 2013. (PMID:23583396)

17.  Li WE, Chen W, Ma YF, Tuo QR, Luo XJ, Zhang T, Sai WB, Liu J, Shen J, Liu ZG, Zheng YM, Wang YX, Ji G, Liu Q-H*. Methods to measure and analyze ciliary beat activity: Ca2+ influx-mediated cilia mechanosensitivity. Pflügers Archiv-European Journal of Physiology. 464(6):671-80, 2012. (PMID:23053477)

四、教学活动及其成果:

(一)承担课程(本科生、研究生)
《动物生理学》,生科院,本科生;
《科技论文学作》,生科院,研究生;

《现代传染病学》,所有院系,在校学生。

(二)教学成果及荣誉

      无

五、社会服务活动及其成果

 (一)参与项目及活动

    无

(二)成果转化及社会效益

    无